Mixed ligand complexes of [Pd(terpy)(H2O)]2+ with some selected amino acids, peptides, DNA and related ligands

Nano metal complexes in cancer therapy, preparation, spectroscopic, characterization and anti-breast cancer activity of new metal complexes of alanine Schiff-base.

“…Table (4 The cytotoxic activity of the ligand H3L (1) and some of its metal complexes (15), ( 18) and (19) was evaluated against human breast cancer (MCF-7) cell within 0.1-500 g/L concentration range as shown in figure (2). The IC50 values were calculated for each compound and the results are presented in Figure (3) and Table (7). As shown, mostcomplexess displayed significantly cytotoxic activities compared to standard drug (Doxorubicin).…”

“…By this mechanism strand break occurs as well as the release of the free bases. Another form of attack on the DNA bases is by solvated electrons, probably via a similar reaction to those discussed below for the direct effects of radiation on DNA [66][67][68][69][70][71][72][73][74][75] Figure (7);Mean inhibition zone of the ligand and some of its metal complexes( 15), (18), and (19)against breast carcinoma MCF-7.…”

“…Schiff-base ligands have significant importance, especially in the development of Schiff -base complexes, because Schiff-base ligands are potentially capable of forming stable complexes with metal ions [5,6]. Also Schiff -bases have been studied extensively due to their applications in biological, clinical, analytical and pharmacological study [7][8]. Solvent free synthesis by microwave irradiation technique has been done and this technique is rapid and efficient and very economical.…”

Oxidative DNA cleavage mediated by a new unexpected [Pd(BAPP)][PdCl4] complex (BAPP = 1,4-bis(3-aminopropyl)piperazine): crystal structure, DNA binding and cytotoxic behavior

“…As reported before, under physiological conditions, the metal complexes possessing efficient DNA binding and cleavage propensities are mostly considered as drugs for cancer treatment and genomic research. [21][22][23] In the light of these facts and in continuation of our previous work on palladium amine complexes, [24][25][26][27][28][29] novel Pd(II) complex, [Pd(BAPP)][PdCl 4 ], based on 1,4-bis(3aminopropyl)piperazine ligand (BAPP) has been synthesized. The unexpected geometrical features were successfully identied by single-crystal X-ray structure analysis and different spectroscopic tools.…”