Mixed-ligand complexes of zinc(II) with 1,1-dicyanoethylene-2,2-dithiolate and N-donor ligands: A combined experimental and theoretical study

Singh, Mahesh Kumar; Sutradhar, Sanjit; Paul, Bijaya; Adhikari, Suman; Laskar, Folguni; Acharya, Sandeep; Chakraborty, Debabrata; Biswas, Surajit; Das, Arijit; Roy, Subhadip; Frontera, Antonio

doi:10.1016/j.molstruc.2018.03.073

Cited by 23 publications

(7 citation statements)

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“…On the other hand, dithiolates of group 12 metals, particularly, Zn and Hg, have been extensively studied because their structural versatility about others, but still provides new insight into metal–ligand interactions. − Additionally, the coordination chemistry of zinc(II) thiolate and dithiolate complexes plays a significant role as model compounds for metalloproteins and fungicides . On the other hand, the affinity of Hg 2+ for sulfur and their accumulative effect in animals and in proteins and enzymes of humans are also well-known because of its thiophilic nature; thus, developing highly stable Hg(II) complexes with soft sulfur donor ligands can be useful for mercury detoxification purposes in biological media. , …”

Section: Resultsmentioning

confidence: 99%

“…34−38 Additionally, the coordination chemistry of zinc(II) thiolate and dithiolate complexes plays a significant role as model compounds for metalloproteins 39 and fungicides. 40 On the other hand, the affinity of Hg 2+ for sulfur and their accumulative effect in animals and in proteins and enzymes of humans are also well-known because of its thiophilic nature; thus, developing highly stable Hg(II) complexes with soft sulfur donor ligands can be useful for mercury detoxification purposes in biological media. 41,42 Therefore, we have carried out the reaction between MOH (M = Na or K) and the dithiolene HSC 6 H 4 SH in the presence of HgCl 2 under argon atmosphere.…”

Section: Methodsmentioning

confidence: 99%

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Structural Factors Governing the Formation of Extended Structures in Group 10 and 12 Metal-Dithiolenes

Castillo

Delgado

Hernández

et al. 2020

Crystal Growth & Design

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A series of metal-dithiolene compounds have been prepared by direct reactions between MCl2·6H2O (M = Ni, Zn) or HgCl2 with HSC6H2X2SH (X = Cl or H) in the presence of a base. The fine-tuning of the reaction conditions has allowed us to rationalize part of the structural factors governing the formation of coordination polymers versus discrete metal-dithiolene complexes. With the aim to gain knowledge of the formation of extended metal–organic structures, we have also studied the reaction between Na[Ni(SC6H2Cl2S)2] and HgCl2. These reactions lead to the formation of either discrete compounds or extended structures. The detailed structural analysis of 11 compounds has allowed us to uncover some relevant clues about the formation of coordination polymers based on dithiolenes. We have observed that extended structures are typically formed when: (i) the sulfur atoms apart from being involved in the chelation of the transition metal center also coordinate to the alkaline metal center; i.e., dithiolene acts as a bridging ligand; (ii) water molecules preferentially coordinate to alkaline centers mostly acting as bridging molecules; and (iii) bulkier alkaline cations are employed to allow a greater number of sulfur atoms coming from the metal-dithiolene entities to be incorporated in their coordination sphere. The results obtained ensure that a combination of at least two of these features gives rise to polymeric coordination entities.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Structural Factors Governing the Formation of Extended Structures in Group 10 and 12 Metal-Dithiolenes

Castillo

Delgado

Hernández

et al. 2020

Crystal Growth & Design

View full text Add to dashboard Cite

show abstract

“…This investigation took place in the presence of two distinct N-donor ligands viz. α-picoline (2-methylpyridine) and γ-picoline (4-methylpyridine) [14]. The outcome of this study yielded two distinct Zn(II) coordination complexes.…”

Section: Introductionmentioning

confidence: 93%

“…According to the findings, these ligands form a tetrametallic-tetraconnective (µ 2 -µ 2 ) bonding mode [11,12]. Further, the complexes of mixed ligand containing 1,1-dicyanoethylene-2,2-dithiolates also showed diverse structures [13][14][15][16]. Recent studies shows that dithiolate ligands have rigid structures, forms homoleptic complexes and also have highly efficient thermally activated delayed fluorescence in carbene zinc(II) dithiolates [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Transition Metal Complexes: Design, Synthesis, Luminescent Features, Electrical Behaviour, Nanostructure Morphology and Bioactive Properties with 1,1-Dicyanoethylene-2,2-dithiolate and p-Phenylenediamine Ligands

Das,

Hussain,

Banik

et al. 2024

ajc

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Four new transition metal complexes (1-4) were successfully synthesized through the reaction of M(NO3)2·nH2O (M = Ni, Co, Cd or Zn; n = 6 for Ni, Co, Zn; n = 4 for Cd) with 1,1-dicyanoethylene-2,2-dithiolate (i-MNT2–) and p-phenylenediamine (PPD) ligands. The syntheszed metal complexes were characterized by CHN-analysis, electronic, FTIR and 1H NMR spectroscopic techniques. The electronic transition investigations reveals six coordinate octahedral geometry for Ni(II), distorted octahedral for Co(II), four coordinate tetrahedral geometry for Cd(II) and Zn(II) complexes. All the four metal complexes displayed a significant red shift in the absorption maximum, suggesting their successful assembly. The luminescence behaviour exhibited the prominent fluorescence within the visible range. The current-voltage characteristics revealed that complexes 2 and 3 exhibited ohmic behaviour, displaying a linear curve. On the other hand, complexes 1 and 4 initially maintained a low conducting state (OFF state) until a specific voltage threshold (VTh), beyond which the current sharply increased, transitioning to a higher current state (ON state). The FESEM images of the metal complexes strongly indicated a nano-scale aggregated structure. In terms of antibacterial activity, complexes 3 and 4 demonstrated promising efficacy against various bacterial strains, with complex 3 being particularly potent. The fungicidal activity of all four metal complexes was remarkable against Magnaporthe grisea, Cochliobolus miyabeanus and Synchitrium endobioticum, however, no fungicidal activity was found against Trichophyton mentagrophytes and Candida albicans.

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“…At the heart of metallodrugs is coordination chemistry, which explores the interaction between metal ions and ligands. By carefully selecting ligands and metal ions, researchers can fine-tune the chemical properties of metal-based drugs, influencing their stability, reactivity, and biological activity Adhikari et al, 2021;Ghosh et al, 2011;Ghosh et al, 2017;Park et al, 2012;Park et al, 2012;Singh et al, 2017;Singh et al, 2018).…”

Section: Coordination Chemistrymentioning

confidence: 99%

Metal-Based Drugs in Cancer Therapy

Nath,

Datta,

Das

et al. 2024

IJERR

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Metal-based drugs have emerged as pivotal therapeutics in cancer therapy, enlightening a path toward innovative and effective treatment strategies. Platinum-based therapeutics, notably cisplatin, carboplatin, and oxaliplatin, have transformed the landscape of cancer treatment, setting the stage for the development of next-generation metal-based compounds. Delving into the principles governing the design of metal-based drugs, this article navigates through their intricate coordination chemistry, targeted delivery approaches, and mechanisms of action. Notably, metal-based compounds form covalent bonds with DNA, disrupting vital cellular processes and inducing apoptosis in cancerous tissues. Even though contemporary chemotherapy as well as radiotherapeutic methods have greatly increased patient survival rates, disease recurrence still represents a fatal danger. The probability of metastasis and the drug resistance are increased by the incomplete clearance of neoplastic tissues from the body. This review explores the compelling journey of metal-based compounds, from their historical significance in ancient remedies to their pivotal role in modern oncology, and also discusses the recent advancements and emerging trends that promise to shape the future of metallodrugs. The shining promise of metal-based drugs in cancer remedies holds the potential to revolutionize treatment paradigms, offering hope and resilience in the ongoing battle against one of humanity's most relentless adversaries.

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Mixed-ligand complexes of zinc(II) with 1,1-dicyanoethylene-2,2-dithiolate and N-donor ligands: A combined experimental and theoretical study

Cited by 23 publications

References 46 publications

Structural Factors Governing the Formation of Extended Structures in Group 10 and 12 Metal-Dithiolenes

Structural Factors Governing the Formation of Extended Structures in Group 10 and 12 Metal-Dithiolenes

Multifunctional Transition Metal Complexes: Design, Synthesis, Luminescent Features, Electrical Behaviour, Nanostructure Morphology and Bioactive Properties with 1,1-Dicyanoethylene-2,2-dithiolate and p-Phenylenediamine Ligands

Metal-Based Drugs in Cancer Therapy

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