Mixed ligand copper(II) complexes of phenanthroline/bipyridyl and curcumin diketimines as DNA intercalators and their electrochemical behavior under Nafion® and clay modified electrodes

Annaraj, Jamespandi; Srinivasan, S.; Ponvel, Kanagasabai Muruganandam; Athappan, Pr.

doi:10.1016/j.jinorgbio.2004.11.018

Cited by 87 publications

(37 citation statements)

References 23 publications

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“…The decrease in peak current on the addition of DNA to the complex is suggestive of an interaction between the complex and DNA 16 , a decrease in the peak-to-peak separation was observed, which is consistent with non-coordinating intercalative binding of the complexes through the planar aromatic rings between the DNA base pairs 17 . The formal potential Ef shift slightly towards the positive side and is attributed to characteristic behaviour of intercalation of the complexes into the DNA double-helix and suggests that extract bind to DNA at different rates 18 .…”

Section: Electrochemical Methodssupporting

confidence: 58%

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2016

IJPSR

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ABSTRACT:The present research aimed to evaluate the binding effect of hydroalcoholic extracts of leaf and Stem bark of Prosopis cineraria (PCL and PCB) with Calf Thymus (CT) DNA. The interaction of the PCL and PCB with Calf Thymus (CT) DNA has been studied using absorption spectra, viscosity measurements and cyclic voltammetry methods. It was observed that the PCL and PCB exhibited hypochromic and bathochromic shifts in the absorption spectra on binding to DNA which is a typical characteristic of DNA intercalation. In viscosity measurements, varying concentration of PCL and PCB causes a significant increase in viscosity of DNA. The variations of the cyclic voltammetric behavior of both extracts PCL and PCB was noted which demonstrate intercalative interaction between the PCL, PCB and the CT-DNA. In conclusion, both PCL and PCB possessed good DNA-binding abilities. INTRODUCTION:The DNA binding assay forms a theoretic guide for the design of new anticancer drugs and chemical treatments of tumor and virus. They are also very valuable for probing the mechanism of the interaction between anticancer drugs and DNA and establish convenient methods to effectively choose specific anticancer drug. These associative interactions with the DNA molecules can cause dramatic changes in the physiological actions of DNA that might be responsible for the cytotoxic behaviour of the small molecules. Prosopis cineraria Linn is a large tree, which belongs to the family Mimosaceae.

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Section: Electrochemical Methodssupporting

confidence: 58%

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2016

IJPSR

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“…From the structure of curcumin (Scheme 1), it can be said that curcumin has a highly conjugated bdiketone moiety. b-Diketones are long known to form complexes with almost every metal and metalloid [4]. Several metal complexes of curcumin have been synthesized, characterized and evaluated for various biological activities.…”

Section: Introductionmentioning

confidence: 99%

Syntheses, characterization and biological activities of rare earth metal complexes with curcumin and 1,10-phenanthroline-5,6-dione

Song

Ding

et al. 2009

Journal of Inorganic Biochemistry

111

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“…9Accm (Compound 144) and its corresponding copper-complex, [Cu(phen)Cl(9Accm)] for their interactions with calf thymus DNA which indicate a weak electrostatic interaction with the double helix. Annaraj and co-workers [106] have examined the binding mode of ternary copper (II) complexes of Curcumin Schiff bases (145-146) involving phenanthroline/bipyridyl as ancillary ligands with herring sperm DNA by spectral and electrochemical techniques. These studies revealed that interaction with DNA slightly improves reversibility of the quasi-reversible Cu +2/+1 redox couple with considerable reduction in current intensity.…”

Section: Metalmentioning

confidence: 99%

Perspectives on New Synthetic Curcumin Analogs and their Potential Anticancer Properties

Vyas¹,

Dandawate²,

Padhyé³

et al. 2013

Current Pharmaceutical Design

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Curcumin is the active component of dried rhizome of Curcuma longa, a perennial herb belonging to ginger family, cultivated extensively in south and southeastern tropical Asia. It is widely consumed in the Indian subcontinent, south Asia and Japan in traditional food recipes. Extensive research over last few decades has shown that curcumin is a potent anti-inflammatory agent with powerful therapeutic potential against a variety of cancers. It suppresses proliferation and metastasis of human tumors through regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases and other enzymes. It induces apoptotic cell death and also inhibits proliferation of cancer cells by cell cycle arrest. Pharmacokinetic data has shown that curcumin undergoes rapid metabolism leading to glucuronidation and sulfation in the liver and excretion in the feces, which accounts for its poor systemic bioavailability. The compound has, therefore, been formulated and administered using different drug delivery systems such as liposomes, micelles, polysaccharides, phospholipid complexes and nanoparticles that can overcome the limitation of bioavailability to some extent. Attempts to avoid rapid metabolism of curcumin until now have been met with limited success. This has prompted researchers to look for new synthetic curcumin analogs in order to overcome the drawbacks of limited bioavailability and rapid metabolism, and gain efficacy with reduced toxicity. In this review we provide a summarized account of novel synthetic curcumin formulations and analogs, and the recent progress in the field of cancer prevention and treatment.

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Mixed ligand copper(II) complexes of phenanthroline/bipyridyl and curcumin diketimines as DNA intercalators and their electrochemical behavior under Nafion® and clay modified electrodes

Cited by 87 publications

References 23 publications

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Syntheses, characterization and biological activities of rare earth metal complexes with curcumin and 1,10-phenanthroline-5,6-dione

Perspectives on New Synthetic Curcumin Analogs and their Potential Anticancer Properties

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