Mixed-ligand copper(ii)-diimine complexes of 3-formylchromone-N⁴-phenyl thiosemicarbazone: 5,6-dmp co-ligand confers enhanced cytotoxicity

Abstract

The higher DNA binding ability, lipophilicity, reversible CuII/CuI redox behavior, and ability to oxidatively cleave DNA and to produce ROS confers on the 5,6-dmp complex remarkable cytotoxicity (IC50, 1.26 μM) against HeLa cervical cancer cells.