Mixed ligand octahedral Zn(II) complex of N^N^O donor tridentate Schiff base ligand and N^N donor bidentate bipyridine ligand: Synthesis, characterization, biological activity and cytotoxicity

Abstract

Tridentate NNO donor Schiff base ligand and its mixed ligand zinc(II) complex were synthesized stoichiometrically and characterized by electronic, infrared, mass spectral techniques and elemental analysis. To understand the DNA binding ability, the complex was investigated by various analytical and spectroscopic techniques in presence of calf thymus DNA (CT‐DNA). The binding studies showed that the zinc complex interacts with DNA by groove binding mode with intrinsic binding strength of 2.11 × 105 M−1 and with bovine serum albumin the complex showed dynamic quenching attributed for changes in the secondary structure of BSA with efficient interaction. The MCF‐7 cell line studies of the zinc(II) complex with 90.8 μM IC50 value revealed that the complex is effective for the breast cancer cell line and has a potential as anticancer drug. Furthermore, the tridentate ligand and its mixed ligand zinc complex were screened for antibacterial and antifungal activities, which showed better antimicrobial activity for complex.

Insight into the inhibitory potential of metal complexes supported by (E)-2-morpholino-N-(thiophen-2-ylmethylene)ethanamine: synthesis, structural properties, biological evaluation and docking studies

“…Many of these metal complexes initiate their activity via binding on the DNA molecule and result in the blocking of the division of cancer cells, resulting in cell death. 71 The in vitro cytotoxic potentials of the synthesized ligand and its M( ii ) complexes were screened against those of hepatic cancer HepG2, human colorectal cancer HCT-116, and breast cancer MCF-7 cell lines, and the results are presented in Table 6. The majority of the compounds are more active against the MCF-7 cell line than against the other cell lines.…”

Highly active cobalt(II) and copper(II) complexes supported by aminomethylquinoline mediating stereoselective ring‐opening polymerization of rac‐lactide

“…The stretching vibrations of υ(C=N) quinoline and υ(C=C) quinoline bands appeared at higher wavenumbers (1601–1513 cm −1 ) in the spectra of complexes compared to those of the corresponding uncoordinated ligand 20 . The major peaks at 1100 cm −1 and at 638 and 652 cm −1 in the [LMCl 2 ] spectra (M = Co and Cu) are attributed to the C‐O and M‐N bonds, respectively and these new M‐N bonds also confirmed the complex formation 20,21 …”

“…20 The major peaks at 1100 cm À1 and at 638 and 652 cm À1 in the [LMCl 2 ] spectra (M = Co and Cu) are attributed to the C-O and M-N bonds, respectively and these new M-N bonds also confirmed the complex formation. 20,21 Single-crystal x-ray diffraction studies determined the precise structural nature and properties of the [LMCl 2 ] (M = Co and Cu) (Table S1 and Figure S5). ORTEP drawings of the complexes are shown in Figure 1, and the selected bond lengths and angles are listed in Table S2.…”