Mixed Lymphocyte Culture Search for HLA‐D Homozygous Typing Cells in the Hungarian Inbred Population of Ivád

Abstract

Six functionally HLA-D homozygous typing cells were identified by a restricted investigation into the Hungarian inbred population of Ivád. These putative HLA-D homozygous typing cells were then tested against a highly selected Scandinavian population sample of 60 individuals previously typed by histocompatibility reference reagents. The different HLA-D specificities could thus be identified: one closely matching HLA-Dw5, another resembling the Oslo LDoH specificity, while the last seems to be unique. Only one of the typing cells thus ascertained were HLA-B homozygous and were selected on the basis of the Ivád family structure and not on the basis of serological HLA typing.

Studies of the HLA—D Determinants in the Hungarian Population

“…0255 represents a specificity differing from both. These findings again support our former results gained on the Aarhus panel and direct comparative MLC studies (Onody et al 1978).…”

“…Level ofsignificance: * * * P < 0.001 P < 0.01 * P < 0.05 * * and by HTCs identified in a Hungarian inbred population (Onody et al 1978). The Aarhus panel was closely matched with cells from the Sixth and Seventh Histocompatibility Testing Workshops.…”