Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Rajagopal, Gopalan; Nivetha, A.; Sundar, Madasamy; Panneerselvam, Theivendran; Murugesan, Sankaranarayanan; Pavadai, Parasuraman; Kumar, Sattanathan; Ilango, Sakkanan; Kunjiappan, Selvaraj

doi:10.1016/j.heliyon.2021.e07360

Cited by 56 publications

(21 citation statements)

References 56 publications

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“…Previous articles on the oxidation of different Cu NPs have reported that those studies are incomplete, and learning about the initial oxidation and oxidation progress through time in different environmental conditions is needed [37]. The value of this knowledge is to learn the oxidation degree of the Cu NPs after storage and to know the role of the coating in the chemical stability [38][39].…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Copper Nanoparticles Using Stem Extract of Musa sapientum and Its Characterisation: an in vitro Study

Sowbaraniya

Ganesh

Rajeshkumar

2021

JPRI

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Introduction: Metallic nanoparticles (NPs) have attracted great interest because of their unique physical and chemical properties and among which copper nanoparticles are used for its low cost, better efficacy and environmentally friendly. Musa sapientum has been considered as one of the best medicinal value plants and can be used for the treatment of various periodontal diseases. The aim of the study is to synthesize and characterize Musa sapientum mediated copper nanoparticles. Materials and Methods: The Copper nanoparticles (CuNPs) were synthesized using Musa sapientum extract and characterization was done by UV-Visible Spectroscopy and Transmission Electron Microscope (TEM). Results: The results confirmed that the synthesized Musa sapientum mediated nanoparticle was eco-friendly and non-toxic. The peak value has been centered at 75 nm, which has been mainly associated with absorbance of CuNPs. Absorbance rate increases with increase in wavelength. The formation of CuNPs as well as their morphological dimensions in the TEM study demonstrate that the average size is from 5.67 – 9.10 nm. The shapes of the CuNPs are proved to be spherical. TEM analysis reveals that the copper nanoparticles are predominantly spherical. The overall morphology of the copper nanoparticles produced by reduction of cu2+ ions with 2Mm CUSO4 is composed of almost uniform nanoparticles. Conclusion: In this study, a simple, biological and low-cost approach was done for the preparation of copper nanoparticles using stem extract of Musa sapientum. Thus Musa sapientum mediated copper nanoparticles can be subjected to the various other biological activities such as antibacterial, antifungal, cytotoxic evaluation to know the efficiency of these nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Green Synthesis of Copper Nanoparticles Using Stem Extract of Musa sapientum and Its Characterisation: an in vitro Study

Sowbaraniya

Ganesh

Rajeshkumar

2021

JPRI

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“…For example, Ahamed et al [ 103 ] found that copper ferrite (CuFe 2 O 4 ) nanoparticles (NPs) added to the culture of human breast cancer MCF-7 cells can cause intracellular oxidation stress response, exerting anti-cancer effects, specifically manifested in the production of ROS and the consumption of glutathione (GSH) ( Figure 3 ). Furthermore, Rajagopal et al [ 104 ] found that copper nanoparticles (Wt-CuNPs) have obvious cytotoxic effects on MCF-7 cells. The specific mechanism is mainly due to the release of copper ions from the nanoparticles and the binding of copper ions to tumor cell DNA, causing DNA damage and the resulting apoptotic cell death.…”

Section: Clinical Application Of Copper-based Nanoparticles In Oncologymentioning

confidence: 99%

Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics

Tsymbal

Agadzhanian

et al. 2022

Molecules

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Treatment of drug-resistant forms of cancer requires consideration of their hallmark features, such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways. Malignant cells differ from their normal counterparts in numerous aspects, including copper metabolism. Intracellular copper levels are elevated in various cancer types, and this phenomenon could be employed for the development of novel oncotherapeutic approaches. Copper maintains the cell oxidation levels, regulates the protein activity and metabolism, and is involved in inflammation. Various copper-based compounds, such as nanoparticles or metal-based organic complexes, show specific activity against cancer cells according to preclinical studies. Herein, we summarize the major principles of copper metabolism in cancer cells and its potential in cancer theranostics.

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“…Later, enough Na + and Cl − counter ions were introduced to keep the salt concentration in the complex system at 0.15 M. From the NPT (Isothermal-Isobaric, constant number of particles, pressure, and temperature) equilibration, each complex was assigned a simulation time of 50 ns for the final run. Using the internet server "WebGRO" for macromolecular simulations (https://simlab.uams.edu/), the root mean square deviation (RMSD), root mean square fluctuation (RMSF), radiation of gyration (RGY), and SASA (solvent accessible surface area) of the trajectory analysis were executed in the GROMACS simulation program [47].…”

Section: Molecular Dynamics (Md) Simulation Studiesmentioning

confidence: 99%

Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach

et al. 2022

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Plants and their derived molecules have been traditionally used to manage numerous pathological complications, including male erectile dysfunction (ED). Mimosa pudica Linn. commonly referred to as the touch-me-not plant, and its extract are important sources of new lead molecules in drug discovery research. The main goal of this study was to predict highly effective molecules from M. pudica Linn. for reaching and maintaining penile erection before and during sexual intercourse through in silico molecular docking and dynamics simulation tools. A total of 28 bioactive molecules were identified from this target plant through public repositories, and their chemical structures were drawn using Chemsketch software. Graph theoretical network principles were applied to identify the ideal target (phosphodiesterase type 5) and rebuild the network to visualize the responsible signaling genes, proteins, and enzymes. The 28 identified bioactive molecules were docked against the phosphodiesterase type 5 (PDE5) enzyme and compared with the standard PDE5 inhibitor (sildenafil). Pharmacokinetics (ADME), toxicity, and several physicochemical properties of bioactive molecules were assessed to confirm their drug-likeness property. Molecular dynamics (MD) simulation modeling was performed to investigate the stability of PDE5–ligand complexes. Four bioactive molecules (Bufadienolide (−12.30 kcal mol−1), Stigmasterol (−11.40 kcal mol−1), Isovitexin (−11.20 kcal mol−1), and Apigetrin (−11.20 kcal mol−1)) showed the top binding affinities with the PDE5 enzyme, much more powerful than the standard PDE5 inhibitor (−9.80 kcal mol−1). The four top binding bioactive molecules were further validated for a stable binding affinity with the PDE5 enzyme and conformation during the MD simulation period as compared to the apoprotein and standard PDE5 inhibitor complexes. Further, the four top binding bioactive molecules demonstrated significant drug-likeness characteristics with lower toxicity profiles. According to the findings, the four top binding molecules may be used as potent and safe PDE5 inhibitors and could potentially be used in the treatment of ED.

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Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Cited by 56 publications

References 56 publications

Green Synthesis of Copper Nanoparticles Using Stem Extract of Musa sapientum and Its Characterisation: an in vitro Study

Green Synthesis of Copper Nanoparticles Using Stem Extract of Musa sapientum and Its Characterisation: an in vitro Study

Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics

Aphrodisiac Performance of Bioactive Compounds from Mimosa pudica Linn.: In Silico Molecular Docking and Dynamics Simulation Approach

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