We report on the calculation of mixed QCD-electroweak corrections to the neutral-currentmediated production of a pair of massless leptons in the high invariant mass region. We find these corrections to be O(−1%) at relatively low values of the dilepton invariant mass, around 200 GeV. For invariant masses larger than 1 TeV, we observe that mixed corrections are larger, O(−3%), and are well reproduced by the product of next-to-leading order QCD and electroweak corrections. These results emphasise the importance of mixed QCD-electroweak corrections in Drell-Yan process studies, where percent-level precision is being targeted.