Mixed renomedullary tumor: renal cell carcinoma associated with angiomyolipoma

Schujman, E; Meiraz, D.; Liban, E; Servadio, C

doi:10.1016/0090-4295(81)90274-0

Cited by 21 publications

(13 citation statements)

References 2 publications

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“…Various reports have also described involvement of regional lymph nodes, spleen, liver and pelvic tissue 4 . Sarcomatous transformation of AMYL 5 and an association of AMYL with renal cell carcinoma (RCC) in a separate lesion 3 , 6 –9 or in the same lesion 10 –15 have been reported. In the present report, we describe two cases of an intimate association of AMYL and RCC in the same lesion and discuss the pathogenesis and clinical significance of this association.…”

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confidence: 99%

Composite renal cell carcinoma and angiomyolipoma: A study of the histogenetic relationship of the two lesions

Perkins

Robertson

et al. 1999

Pathology International

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The purpose of the present study was to investigate the possible histogenetic relationship of renal cell carcinoma (RCC) and angiomyolipoma (AMYL) occurring in the same renal nodule by examining two cases of composite RCC and AMYL in patients without stigmata of tuberous sclerosis and by reviewing the medical literature of similar cases. Case 1 represents an epithelioid variant of AMYL with multiple additional nodules of typical AMYL in a surgically removed kidney. The patient subsequently developed a lesion consisting of a mixture of epithelioid variant of AMYL and RCC 24 months later in the retroperitoneum and, an additional 4 months later, in the liver. The RCC cells resembled mononucleated epithelioid cells of the epithelioid AMYL except that they were focally reactive with epithelial membrane antigen (EMA) in the retroperitoneum and focally reactive with both EMA and cytokeratin (CK) in the liver. Case 2 consisted of a typical AMYL admixed with a chromophil cell RCC. A review of the medical literature revealed seven additional cases with histopathological findings similar to this case. All cases had multiple foci of typical AMYL. Immunostaining results are available in five tumors. Chromophil RCC showed variable reactivity with CK and EMA. In addition, RCC in the two cases in the present study also displayed a positive reaction with mucin staining and a positive reactivity with carcinoembryonic antigen. There appears to be a spectrum of histopathological and immunohistochemical changes from the epithelioid variant of AMYL through a mixed epithelioid AMYL/RCC to chromophil RCC in three successive specimens in case 1. Moreover, the intimate admixture of AMYL and RCC and the similar expression of epithelial markers of RCC in the two cases in the present study, as well as other cases in the literature, suggest that some RCC develop from the same precursor cell as AMYL or from a component of AMYL.

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confidence: 99%

Composite renal cell carcinoma and angiomyolipoma: A study of the histogenetic relationship of the two lesions

Perkins

Robertson

et al. 1999

Pathology International

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“…Concomitant renal cell carcinoma was observed in 26% of patients with angiomyolipoma and tuberous sclerosis, while 2–7% of patients with pure renal angiomyolipoma had evidence of renal cell carcinoma. 4,21–26 …”

Section: Discussionmentioning

confidence: 99%

Lymph nodal involvement by renal angiomyolipoma

Koksal¹,

Tunç²,

Kiliçaslan

et al. 2000

Int J of Urology

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Angiomyolipoma of the kidney is a clonal neoplasm, apparently part of a family of neoplasms derived from perivascular epithelial cells. A 40-year-old woman presented with right flank pain and an otherwise non-significant medical history. An abdominal computed tomography scan revealed an 18 cm solid mass in the mid-portion of the right kidney and multiple perihilar lymph nodes. Presumptive diagnosis was renal cell carcinoma. Right radical nephrectomy and a perihilar lymph node dissection was performed through a Chevron incision for the anticipated diagnosis of renal adenocarcinoma. The renal tumor was diagnosed as angiomyolipoma and a component was identified pathologically in a dissected lymph node. There was no evidence of tumor recurrence in the follow-up period of eight years. The consensus from other studies suggests that this phenomenon is a manifestation of the multicentric nature of angiomyolipoma, rather than due to metastasis. Genetic studies may resolve this question in the future.

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“…The finding of a discrete focus with marked echogenicity against the background of the relatively hypoechoic renal cortex facilitates the sonographic de tection of a fat-containing intraparenchymal renal lesion as revealed by five of our cases. Although highly sugges tive, this pattern is not always pathognomonic, since other causes of echogenic renal nodules, including malig nant tumors such as adenocarcinoma, liposarcoma and lymphoma, benign tumors such as lipoma, oncocytoma or cavernous hemangioma, infarcts and renal sinus lipo matosis on occasion may also exhibit a similar sono graphic pattern [17], Despite these partially high-specific radiological and tomographic findings it should be noted that there might be an association between renal angio myolipoma and renal cell carcinoma as indicated by sev eral reports [19][20][21], Whether the carcinoma originates in an angiomyolipoma or is a coincidental finding re mains unclear. Clinical management of renal angiomyo lipoma remains controversial and must be decided on an individual basis.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Renal Angiomyolipoma (Based on 15 Cases)

Heckl¹,

Osterhage²,

Frohmüller³

1987

Urol Int

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Fifteen cases of renal angiomyolipoma not associated with tuberous sclerosis are presented. The clinical and radiological features, the pathology and the management of these rare but well-documented tumors are discussed. They pose problems in diagnosis, and controversy still exists regarding their management. Additional techniques such as ultrasonography and computerized tomography may help in the diagnosis. When conservative surgery is not possible, or when a solid tumor cannot be confidently excluded, nephrectomy should be performed.

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Mixed renomedullary tumor: renal cell carcinoma associated with angiomyolipoma

Cited by 21 publications

References 2 publications

Composite renal cell carcinoma and angiomyolipoma: A study of the histogenetic relationship of the two lesions

Composite renal cell carcinoma and angiomyolipoma: A study of the histogenetic relationship of the two lesions

Lymph nodal involvement by renal angiomyolipoma

Diagnosis and Treatment of Renal Angiomyolipoma (Based on 15 Cases)

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