Mixed Squamous Cell and Glandular Papilloma of the Lung in a 64-Year-Old Woman

Abstract

Mixed squamous cell and glandular papilloma of the lung is an extremely rare benign epithelial tumor showing a mixture of squamous and glandular epithelium. Here, we report a case of mixed squamous cell and glandular papilloma that presented as a solitary nodule in the left lower lobe of a 64-year-old woman. Chest computed tomography demonstrated a lobulated mass in the basal segment of the left lower lobe. The patient underwent a lobectomy under the suspicion of lung malignancy. The histopathological diagnosis was mixed squamous cell and glandular papilloma.

Expression of p16Ink4a in mixed squamous cell and glandular papilloma of the lung

“…Most patients have a history of smoking, suggesting that smoking is correlated with this tumor. Mixed papilloma typically presents with hemoptysis, cough, or chest pain, but some cases were found by chance without significant symptoms, similarly to in our case . The CT findings of this tumor are often a well‐circumscribed mass in the lung, but also reveal pleural indentation when the tumor is located in a peripheral area .…”

“…SEPs are subclassified into three categories according to histological type: squamous cell papilloma, glandular papilloma, and mixed squamous cell and glandular papilloma (mixed papilloma) . Among these three types, mixed papilloma is the rarest, with only 21 cases in the English literature . Although the expression of p16 Ink4a was analyzed in only two cases of mixed papilloma, these cases were negative for p16 Ink4a .…”

Pulmonary sialadenoma papilliferum and its mimics: what you need to know

“…7,8,11,[18][19][20] SP and GP/MP are similar in tumour location and histological morphology. 21,22 Both SP and GP/MP tumours can originate from the central bronchus, and the superficial portion of both presents papillary growth of columnar epithelium accompanied by basal cells (Figure 3A-D). However, there are differences in the following aspects.…”