Abstract. We introduce a new family of superalgebras, the quantum walled Brauer-Clifford superalgebras BCr,s(q). The superalgebra BCr,s(q) is a quantum deformation of the walled BrauerClifford superalgebra BCr,s and a super version of the quantum walled Brauer algebra. We prove that BCr,s(q) is the centralizer superalgebra of the action of Uq(q(n)) on the mixed tensor space V r,s q⊗s when n ≥ r + s, where Vq = C(q) (n|n) is the natural representation of the quantum enveloping superalgebra Uq(q(n)) and V * q is its dual space. We also provide a diagrammatic realization of BCr,s(q) as the (r, s)-bead tangle algebra BTr,s(q). Finally, we define the notion of q-Schur superalgebras of type Q and establish their basic properties.