Mixed Versus Pure Variants of Desmoplastic Melanoma

Conic, Rosalynn R.Z.; Ko, Jennifer S.; Allam, Sherihan H.; Atanaskova-Mesinkovska, Natasha; Kovalyshyn, Ivanka; Bergfeld, Wilma F.; Gastman, Brian

doi:10.1097/sap.0000000000001225

Cited by 16 publications

(28 citation statements)

References 17 publications

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“…In this study, we found an overall SLNB positivity rate of DM of 9.7% in 62 SLNBs. This is comparable to previous studies with rates ranging from 0% to 18.2% . The sample size in these studies varied from 12 to 505 patients who underwent SLNB, which might account for the wide range of SLNB positivity rates found.…”

Section: Discussionsupporting

confidence: 86%

“…When comparing MDM to PDM in the current study, 6/36 (16.7%) of patients with MDM had a positive SLNB and 0/26 (0%) of the patients with PDM ( P = .0035). In earlier studies with more than 25 SLNBs, positivity rates of MDM ranged from 8.5% to 24.6% and of PDM from 2.2% to 18.2% . All but one study found lower rates for PDM compared to MDM .…”

Section: Discussionmentioning

confidence: 89%

“…In earlier studies with more than 25 SLNBs, positivity rates of MDM ranged from 8.5% to 24.6% and of PDM from 2.2% to 18.2% . All but one study found lower rates for PDM compared to MDM . When stratified for subtype, Dunne et al found SLNB positivity rates for MDM of 13.8% and for PDM of 5.4% (no P ‐value reported).…”

Section: Discussionmentioning

confidence: 97%

“…Murali et al found 11/129 (8.5%) positive SLNBs for MDM and 6/123 (4.9%) for PDM in a total of 252 patients who all underwent SLNB ( P = .25) . Likewise, Conic et al did not find a significant difference between 3/24 (12.5%) positive SLNBs for MDM and 2/11 (18.2%) for PDM ( P = .31) . Han et al showed in multivariable analysis that after correcting for age, mixed subtype was significantly associated with positive SLNB (OR 3.0) in 205 patients with SLNB, of which 15/61 (24.6%) were MDM and 6/67 (9.0%) PDM .…”

Section: Discussionmentioning

confidence: 98%

“…Two other studies reported survival percentages for PDM and MDM: Maurichi et al found an OS of 61.3% for MDM vs 79.5% for PDM ( P < .001) in a total of 242 patients . Conic et al found an OS of 73% for MDM vs 75% for PDM ( P = .53) in 58 patients …”

Section: Discussionmentioning

confidence: 99%

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Desmoplastic melanoma: The role of pure and mixed subtype in sentinel lymph node biopsy and survival

et al. 2019

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Background Desmoplastic melanoma (DM) is an uncommon type of melanoma. Two histological subtypes of DM can be distinguished: pure and mixed (PDM and MDM). We hypothesized that discrimination between these subtypes is associated with sentinel lymph node biopsy (SLNB) status and survival. Methods Clinicopathological data from PALGA, the Dutch Pathology Register were retrieved from patients diagnosed with DM in The Netherlands between 2000 and 2014. Clinical and pathological variables were extracted from pathology text files, including pure or mixed desmoplastic morphology. A Cox proportional hazard model was performed for overall and recurrence‐free survival (OS and RFS). Results A total of 239 patients with DM were included, representing 0.4% of all primary cutaneous melanoma in The Netherlands. A total of 114 PDM and 125 MDM patients were identified. MDM was significantly associated with positive SLNB status (P = .035). In multivariable analysis, age (HR 1.10, 95% CI 1.07‐1.14, P < .001) and ulceration (HR 1.98, 95% CI 1.05‐3.75, P = .036) were significant predictors for OS. For RFS, mixed subtype (HR 2.72 95% CI 1.07‐6.89, P = .035), male gender (HR 2.54, 95% CI 1.03‐6.27, P = .043), and Breslow thickness (HR 1.13 per mm, 95% CI 1.05‐1.21, P = .001) were significant predictors. Conclusion MDM is significantly associated with a positive SLNB status. Mixed subtype is significantly correlated with RFS, but not with OS. The distinction between pure and mixed desmoplastic subtype therefore seems to be of clinical importance.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Desmoplastic melanoma: The role of pure and mixed subtype in sentinel lymph node biopsy and survival

et al. 2019

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Joinpoint regression analysis of recent trends in desmoplastic malignant melanoma incidence and mortality: 15-year multicentre retrospective study

Yu,

Zhu,

Zhang

et al. 2024

Arch Dermatol Res

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BackgroundDesmoplastic Malignant Melanoma (DMM) detection and mortality rates have signi cantly increased in recent years.There are currently no comprehensive epidemiological investigations of DMM incidence and mortality trends.This study aims to explain changes in DMM incidence and mortality during a 15-year term (2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019). MethodsData on DMM patients was sourced from the Surveillance, Epidemiology, and End Results (SEER) database. Both incidence and incidence-based mortality rates were directly extracted from the SEER database. Joinpoint regression was used to analyze and calculate the average annual percent change (AAPC) and its 95% con dence interval (CI). ResultsBetween 2005 and 2019, 3,384 DMM cases were identi ed, boasting an age-adjusted incidence rate of 3.63% (95% CI: 3.51-3.76) and an incidence-based mortality rate of 1.65% (95% CI: 1.57-1.74). Of these, 2,353 were males (69.53%) and 1,031 were females (30.47%). There were 1894 patients (55.97%) who were over 70 years old. Predominantly, DMM lesions manifested in exposed areas: Limbs (955, 28.22%), Face (906, 26.77%), and Scalp and Neck (865, 25.56%). The incidence of DMM increased signi cantly at a rate of APC = 0.9% during 2005-2019, while the incidence-based mortality showed a signi cant upward trend (APC = 7%) during 2005-2012, and slowly increasing trend (APC = 0.6%) during 2012-2019. In contrast to the modest upward trajectory in female incidence and mortality, male incidence initially surged, later declining, while male mortality peaked and stabilized post-2012. The primary sites for incidence and mortality were consistently exposed areas: Face, Scalp and Neck, and Limbs. ConclusionsIn recent years, the incidence and incidence-based mortality of DMM have signi cantly increased. Each subgroup analysis has different trends, and these trends can provide better support for our exploration of DMM.

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Actualización en el diagnóstico y manejo del melanoma desmoplásico

Garcia

Pi-Sunyer

Richarz

et al. 2022

Actas Dermo-Sifiliográficas

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Mixed Versus Pure Variants of Desmoplastic Melanoma

Abstract: Pure and mixed DMs seem to have similar clinical characteristics and outcomes. This indicates that analysis of national datasets without this subclassification remains viable.

Cited by 16 publications

References 17 publications

Desmoplastic melanoma: The role of pure and mixed subtype in sentinel lymph node biopsy and survival

Desmoplastic melanoma: The role of pure and mixed subtype in sentinel lymph node biopsy and survival

Joinpoint regression analysis of recent trends in desmoplastic malignant melanoma incidence and mortality: 15-year multicentre retrospective study

Actualización en el diagnóstico y manejo del melanoma desmoplásico

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