Mixing Behavior of Cationic Hydrotropes with Anionic Surfactant Sodium Dodecyl Sulfate

Khan, Ziya Ahmad; Kamil, Mohammad; Sulaiman, Othman; Hashim, Rokiah; Ibrahim, Mohamad Nasir Mohamad; Khanam, Ahmad Jahan; Kabir-ud-Din, †

doi:10.1080/01932691.2010.513307

Cited by 11 publications

(7 citation statements)

References 23 publications

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“…There are few cationic hydrotropes known, 1 and only in the past few years some sparse studies using quaternary ammonium-based salts were reported. 70–72 In summary, the results obtained here clearly support that ILs may constitute a novel series of cationic hydrotropes.…”

Section: Resultssupporting

confidence: 72%

The magic of aqueous solutions of ionic liquids: ionic liquids as a powerful class of catanionic hydrotropes

et al. 2015

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Hydrotropes are compounds able to enhance the solubility of hydrophobic substances in aqueous media and therefore are widely used in the formulation of drugs, cleaning and personal care products. In this work, it is shown that ionic liquids are a new class of powerful catanionic hydrotropes where both the cation and the anion synergistically contribute to increase the solubility of biomolecules in water. The effects of the ionic liquid chemical structures, their concentration and the temperature on the solubility of two model biomolecules, vanillin and gallic acid were evaluated and compared with the performance of conventional hydrotropes. The solubility of these two biomolecules was studied in the entire composition range, from pure water to pure ionic liquids, and an increase in the solubility of up to 40-fold was observed, confirming the potential of ionic liquids to act as hydrotropes. Using dynamic light scattering, NMR and molecular dynamics simulations, it was possible to infer that the enhanced solubility of the biomolecule in the IL aqueous solutions is related to the formation of ionic-liquid-biomolecules aggregates. Finally, it was demonstrated that hydrotropy induced by ionic liquids can be used to recover solutes from aqueous media by precipitation, simply by using water as an anti-solvent. The results reported here have a significant impact on the understanding of the role of ionic liquid aqueous solutions in the extraction of value-added compounds from biomass as well as in the design of novel processes for their recovery from aqueous media.

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Section: Resultssupporting

confidence: 72%

The magic of aqueous solutions of ionic liquids: ionic liquids as a powerful class of catanionic hydrotropes

et al. 2015

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“…It is observed that even at the highest temperature studied, the change of slope is clearly noticeable. Our results show that the cmc of pure surfactants agree well with the literature ,− values and also the MHC values of pure hydrotropes. ,, …”

Section: Resultssupporting

confidence: 90%

Analysis of Mixed Micellar Behavior of Cationic Gemini Alkanediyl-α,ω-bis(dimethylcetylammonium bromide) Series with Ionic and Nonionic Hydrotropes in Aqueous Medium at Different Temperatures

et al. 2011

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The interaction between cationic symmetrical gemini alkanediyl-α,ω-bis(dimethylcetylammonium bromide) series (16-s-16, s = 5, 6, abbreviated as G5 and G6) with hydrotropes (cationic: aniline hydrochloride, para-toluidine hydrochloride, and ortho-toluidine hydrochloride; nonionic: phenol, resorcinol, and pyrogallol) in aqueous medium has been investigated at four different temperatures ranging from 298.15 to 313.15 K. Different physicochemical parameters such as critical micelle concentration (cmc), interaction parameter (β(m), an energetic parameter that represents the excess Gibbs free energy of mixing), activity coefficients (f(i)), mole fraction of hydrotrope in mixed micelles at ideal mixing conditions (X(1)(ideal))(,) excess free energy of mixing (Δ(mix)G(E)), standard enthalpy (Δ(mic)H°), entropy (Δ(mic)S°), and Gibbs free energy (Δ(mic)G°) of micellization were evaluated and then intracompared. For further understanding, similar studies were carried out with their conventional counterpart cetyltrimethyl ammonium bromide (CTAB) and then compared. The bulk behaviors were explored using different theoretical models of Clint, Rubingh, and Motomura for justification and comparison of results of different binary combinations of hydrotropes with the gemini series and CTAB. Synergistic interaction was observed in all binary combinations at all temperatures in the micelles which decreases slightly with increasing temperature. This study will give insight into the selection of surfactants in different applications as their properties get modified by interaction with hydrotropes, thus influencing their solution behavior which, in turn, modifying the phase-forming behavior, microemulsion, liquid crystal forming systems, clouding phenomenon, cleaning, and laundry processes besides solubilization. The ability of hydrotropes to dramatically alter the solubility of other molecules in a medium can be exploited for the purpose of selective encapsulation and release.

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“…The obtained cmc values of pure compounds and their mixtures in different ratio and temperatures are shown in Tables in absence and presence of NaCl. The value of cmc in case of pure drug at 298.15 K was obtained to be 35.05 mmol kg −1 , which is close to earlier reported value, and value of the mhc of pure hydrotropes was also in fine agreement with the earlier accounted value . As, it is clear from the PMZ structure (Scheme ) the hydrophobic portion of PMZ monomer is small and rigid.…”

Section: Resultsmentioning

confidence: 98%

Solution properties of phenothiazine drug promazine hydrochloride with cationic hydrotropes in aqueous/electrolyte solution at different temperature

Rub

Azum

Asiri

et al. 2016

J. Phys. Org. Chem.

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aThe current work deals with the mixed micellization phenomena of surface active promazine hydrochloride (PMZ) drug with cationic hydrotropes (para-toluidine hydrochloride and ortho-toluidine hydrochloride) in absence and occurrence of 50 mmol kg À1 NaCl at five different temperature (293.15-313.15 K). PMZ is an amphiphilic phenothiazine drug and employed for the cure of mania and schizophrenia. Conductometry measurement was employed to gain a detailed picture of the interactions between drug and hydrotrope molecules. The experimental data were analyzed according to different mixing models within the outline of the pseudophase separation model. The evaluated values of critical micelle concentration (cmc) were found to be inferior than cmc id values signifying attractive interactions involving the both components in the solutions. NaCl further reduces the cmc of pure amphiphiles and their mixed systems as a result of screening of the electrostatic repulsion between the polar head groups. The micellar mole fractions (X 1 ) of hydrotropes evaluated by various proposed models were constantly more than ideal values (X id 1 ) signifying high involvements of hydrotrope in mixed micelles. Activity coefficients (f Rub 1 and f Rub 2 ) were always below one in all cases signifying synergism in mixed micelles. Thermodynamic parameters favor the process of micellization which is found to be entropy driven. The negative values of free energies of mixing demonstrated the stability of the mixed systems of drug and hydrotrope.

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Mixing Behavior of Cationic Hydrotropes with Anionic Surfactant Sodium Dodecyl Sulfate

Cited by 11 publications

References 23 publications

The magic of aqueous solutions of ionic liquids: ionic liquids as a powerful class of catanionic hydrotropes

The magic of aqueous solutions of ionic liquids: ionic liquids as a powerful class of catanionic hydrotropes

Analysis of Mixed Micellar Behavior of Cationic Gemini Alkanediyl-α,ω-bis(dimethylcetylammonium bromide) Series with Ionic and Nonionic Hydrotropes in Aqueous Medium at Different Temperatures

Solution properties of phenothiazine drug promazine hydrochloride with cationic hydrotropes in aqueous/electrolyte solution at different temperature

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