Mixing characterisation of full-scale membrane bioreactors: CFD modelling with experimental validation

Brannock, Matthew; Wang, Yuan; Leslie, Greg

doi:10.1016/j.watres.2010.02.029

Cited by 97 publications

(54 citation statements)

References 36 publications

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“…Flux reduction is commonly implemented as a sustainable permeability operation (i.e., at a lower flux to maintain stable operation) or as an intermittent operation (i.e., at a higher operating flux with intermittent remedial measures such as relaxation and/or backwashing). As for (iv), aeration is acknowledged to be the main mixing mechanism [137,138] that generates a large amount of momentum that in turn reduces dead-zones and short-circuiting [139]. More details on aeration are given in Section 6.2.…”

Section: Blocking and Blocking Mitigation In Submerged Hf Modulesmentioning

confidence: 99%

The Performance and Fouling Control of Submerged Hollow Fiber (HF) Systems: A Review

et al. 2017

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Abstract:The submerged membrane filtration concept is well-established for low-pressure microfiltration (MF) and ultrafiltration (UF) applications in the water industry, and has become a mainstream technology for surface-water treatment, pretreatment prior to reverse osmosis (RO), and membrane bioreactors (MBRs). Compared to submerged flat sheet (FS) membranes, submerged hollow fiber (HF) membranes are more common due to their advantages of higher packing density, the ability to induce movement by mechanisms such as bubbling, and the feasibility of backwashing. In view of the importance of submerged HF processes, this review aims to provide a comprehensive landscape of the current state-of-the-art systems, to serve as a guide for further improvements in submerged HF membranes and their applications. The topics covered include recent developments in submerged hollow fiber membrane systems, the challenges and developments in fouling-control methods, and treatment protocols for membrane permeability recovery. The highlighted research opportunities include optimizing the various means to manipulate the hydrodynamics for fouling mitigation, developing online monitoring devices, and extending the submerged HF concept beyond filtration.

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Section: Blocking and Blocking Mitigation In Submerged Hf Modulesmentioning

confidence: 99%

The Performance and Fouling Control of Submerged Hollow Fiber (HF) Systems: A Review

et al. 2017

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“…In these three phase processes, the microbial community -in the form of a solid phase -is responsible for biodegradation of pollutants, and availability of enough oxygen for biological reactions is considered a critical factor which emphasizes the importance of an appropriate air supply to the bioreactor. Activated sludge bioreactors are usually agitated pneumatically, and their efficiency is greatly affected by the hydrodynamic conditions within them [4][5][6][7]. For a specific configuration and under otherwise constant operating conditions, two key factors influencing the hydrodynamics inside these bioreactors are: (1) the mode and rate of aeration, and (2) the rheological properties of activated sludge.…”

Section: Introductionmentioning

confidence: 99%

“…Generally, mixing time is one of the most important hydrodynamic characteristics in different types of chemical engineering reactors, and it is also considered as a determinant parameter for design and scale up purposes [6,19,33]. Some techniques such as dye addition [34], conductivity probe [35], radioactive liquid tracer [36], and thermocouple-based methods [37] have been used by many researchers for mixing time measurements.…”

Section: Introductionmentioning

confidence: 99%

Analysis of gas phase characteristics and mixing performance in an activated sludge bioreactor using electrical resistance tomography

Babaei

Bonakdarpour

Ein‐Mozaffari

2015

Chemical Engineering Journal

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“…Prior to solving the tracer equation, the flow field is simulated by the momentum equation. The mixing time predicted can match the experimental data from the different scale mixing tanks [17]. Multiple reactions, bulk reaction, and reaction in surface reaction and porous region can also be modeled [9].…”

Section: First Principles Of Modeling Approachesmentioning

confidence: 98%

Application of Mechanistic Models for Process Design and Development of Biologic Drug Products

Chen

Gandhi

et al. 2016

J Pharm Innov

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Modeling approaches play a valuable role at various stages of development and life-cycle management of biopharmaceutical products. In Quality-by-Design (QbD) paradigm, quality needs to be designed into the product rather than merely confirming it through end product testing; this requires in-depth understanding of the product quality and impact of manufacturing process on product quality (Group IEW 2005. Modeling strategies in support of QbD paradigm for biologics are particularly important because of the costs involved in the development of biologic products (Group CBW 2009; Fissore and Antonello (Qual Des Biopharm Drug Prod Dev 18:565-93, 2015)). This mini-review focuses on the application of mechanistic models in the development of biologic drug products as ready-to-use solutions or lyophilized drug products. The choice of the modeling approach is dependent on the specific processes involved in the unit operation as well as intent of application of modeling. The application of models to unit operations in biologics drug product processing such as mixing (compounding), membrane transfer (ultrafiltration/diafiltration), freeze-thaw, and lyophilization, to characterize the quality risks, define the design space, provide input to control strategy, and build robustness in the process will be discussed.

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Mixing characterisation of full-scale membrane bioreactors: CFD modelling with experimental validation

Cited by 97 publications

References 36 publications

The Performance and Fouling Control of Submerged Hollow Fiber (HF) Systems: A Review

The Performance and Fouling Control of Submerged Hollow Fiber (HF) Systems: A Review

Analysis of gas phase characteristics and mixing performance in an activated sludge bioreactor using electrical resistance tomography

Application of Mechanistic Models for Process Design and Development of Biologic Drug Products

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