“…However, some have recognised its importance 4-6,24-27 , although often focussing on reproducibility rather than generalisability 6,25 , or without using external data 7,26 . Furthermore, we built upon the growing body of research on deep clustering 3,17,19,[28][29][30] by creating X-DEC. The generalisability of clustering models on a general ICU patient population shows that clusters could potentially be used for patient strati cation in clinical research and, eventually, guide clinicians in designing patient-speci c care pathways.…”