1985
DOI: 10.1063/1.1138345
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Mixing liquids in microseconds

Abstract: An instrument is described in which two solutions can be homogeneously mixed within several microseconds. The liquids flow separately through two coaxial capillaries with conical tips and then simultaneously around a sphere (50–100 μ in diameter) which has been positioned close to the end of the outer tip. The liquids flow with velocities of ∼100 m/s through the small passages (∼5 μ wide) separating the sphere and the wall of the outer capillary and mix in the turbulent liquid flow behind the sphere. The mixed… Show more

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Cited by 104 publications
(84 citation statements)
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“…Earlier versions of this experiment involved point-by-point sampling of the reaction profile while maintaining constant flow at high rates (several ml/s for a conventional mixer). The prohibitive amounts of sample consumed limited the impact of continuous-flow techniques until advances in mixer design made it possible to achieve highly efficient mixing at lower flow rates, 70,72,75,120 and an improved detection scheme allowed simultaneous recording of a complete reaction profile in a few seconds. 72 These developments lowered both the dead time and sample consumption by at least an order of magnitude, and made routine measurements on precious samples with dead times as short as 50 μs possible.…”
Section: Continuous-flow Techniquesmentioning
confidence: 99%
“…Earlier versions of this experiment involved point-by-point sampling of the reaction profile while maintaining constant flow at high rates (several ml/s for a conventional mixer). The prohibitive amounts of sample consumed limited the impact of continuous-flow techniques until advances in mixer design made it possible to achieve highly efficient mixing at lower flow rates, 70,72,75,120 and an improved detection scheme allowed simultaneous recording of a complete reaction profile in a few seconds. 72 These developments lowered both the dead time and sample consumption by at least an order of magnitude, and made routine measurements on precious samples with dead times as short as 50 μs possible.…”
Section: Continuous-flow Techniquesmentioning
confidence: 99%
“…Among these approaches, turbulent mixing methods (Roder et al, 2004) have the advantage of being able to take advantage of all of the delivered flux in the X-ray beam for the best signalto-noise ratio (S/N). Turbulence-based mixers use highReynolds-number flow (Re > 10 3 ) in a micromachined channel to reduce the size of the largest eddies to $ 0.1 mm (Roder et al, 2004;Regenfuss et al, 1985). The rate-limiting step in mixing is diffusion over this distance, which is determined by the diffusion time, t d = 2 /D, where is the diffusion length and D is the translational diffusion coefficient (typically $ 10 À5 cm 2 s À1 for small molecules and $ 10 À7 cm 2 s À1 for biological macromolecules).…”
Section: Introductionmentioning
confidence: 99%
“…For example, Regenfuss et al (1985) and Bökenkamp et al (1998) applied turbulent-jet and multiple T-shaped turbulent flows, respectively, to study fast chemical reactions at millimeter-sized scales. Nonetheless, it is much more difficult to generate turbulence at microscales due to the higher viscous dissipation at small Reynolds numbers (Raynal & Gence, 1997).…”
Section: Introductionmentioning
confidence: 99%