Mixing with bubbles: a practical technology for use with portable microfluidic devices

Garstecki, Piotr; Fuerstman, Michael J.; Fischbach, Michael A.; Sia, Samuel K.; Whitesides, George M.

doi:10.1039/b510843h

Cited by 154 publications

(141 citation statements)

References 49 publications

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“…83 Other passive mixing methods use droplets as microreaction chambers 84 or bubbles to promote chaotic advection. 85 Droplet formation on a disc, in which the small diameter of the microreaction chambers significantly reduces the diffusion distance of any reactants, has been demonstrated by Haeberle et al 84 Bubble mixing using T-junctions has not yet been integrated on a disc, possibly due to the constraint of the disc's footprint size, but it could be implemented in the future.…”

Section: Mixingmentioning

confidence: 99%

Lab-on-a-CD: A Fully Integrated Molecular Diagnostic System

et al. 2016

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The field of centrifugal microfluidics has experienced tremendous growth during the past 15 years, especially in applications such as lab-on-a-disc (LoD) diagnostics. The strength of LoD systems lies in its potential for development into fully integrated sample-to-answer analysis systems. This review highlights the technologies necessary to develop the next generation of these systems. In addition to outlining valving and other fluid-handling operations, we discuss the recent advances and future outlook in four categories of LoD processes: reagent storage, sample preparation, nucleic acid amplification, and analyte detection strategies.

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Section: Mixingmentioning

confidence: 99%

Lab-on-a-CD: A Fully Integrated Molecular Diagnostic System

et al. 2016

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“…Air bubbles have been used for a variety of applications such as mixers 14 , valves 15 , pumps 16 , and performing Boolean logic 17 . The bubbles can be either passively positioned using fluidics or actively positioned using various methods such as dielectrophoresis 18 , electrowetting 19 , optoelectrowetting 20 , evaporation 21 , and thermal gradient 22 .…”

Section: Thermocapillary Movement Of Air Bubblesmentioning

confidence: 99%

SPIE Members Get Free Paper from Digital Library

Sheehan¹

2008

SPIE Professional

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Optofluidics1 is the process of integrating the capabilities of optical and fluidic systems to achieve novel functionalities that can benefit from both. Among the novel capabilities that an optical system can bring to the table is the ability to manipulate objects of interest in a liquid media. In the case of biological samples, the objects of interest consist mainly of cells and viruses, whereas in applications such as nanoelectronics, manipulation of nanoparticles is of interest. In recent years, optoelectronic tweezers 2 (OET) has emerged as a powerful technique for manipulation of microscopic particles such as polystyrene beads, cells, and other biological samples and nanoscopic objects such as nanowires.In this paper, we will focus mostly on recent advances in the optoelectronic tweezers technology, including characterization of optoelectronic tweezers operational regimes, manipulation of biological samples such as cells in highconductivity physiological solutions with translation speeds higher than 30 µm/s 3 , manipulation of air bubbles in silicone oil media with speeds up to 1.5 mm/s 4 , and exploring the limits on the smallest particle that OET is capable of trapping 5 . These advances all contribute immensely to the functionalities of OET as an optofluidic system.

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“…[4][5][6][7] In a microfluidic system, flow features, which in a large part determine the manipulation functions of the system, [8][9][10][11] can be obtained by regulating the structure of the microchannels. The microvortex, a special fluid effect generated in sudden expansion or curved microchannels, is of great importance for particle manipulation.…”

Section: Introductionmentioning

confidence: 99%

Lattice Boltzmann numerical simulation and experimental research of dynamic flow in an expansion-contraction microchannel

et al. 2013

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This paper applies the lattice Boltzmann method (LBM) to a 3D simulation of micro flows in an expansion-contraction microchannel. We investigate the flow field under various inlet flow rates and cavity structures, and then systematically study the flow features of the vortex and Dean flow in this channel. Vortex formation analysis demonstrates that there is no observable vortex generated when the inlet flow rate is low enough. As the inlet flow rate increases, a small vortex first appears near the inlet, and then this vortex region will keep expanding until it fully occupies the cavity. A smaller cavity width may result in a larger vortex but the vortex is less influenced by cavity length. The Dean flow features at the outlet become more apparent with increasing inlet flow rate and more recirculation regions can be observed in the cross-section under over high inlet flow rate. In order to support the simulation results, some experimental processes are conducted successfully. It validates that the applied model can accurately characterize the flow in the microchannel. Results of simulations and experiments in this paper provide insights into the design and operation of microfluidic systems for particle/cell manipulation.

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Mixing with bubbles: a practical technology for use with portable microfluidic devices

Cited by 154 publications

References 49 publications

Lab-on-a-CD: A Fully Integrated Molecular Diagnostic System

Lab-on-a-CD: A Fully Integrated Molecular Diagnostic System

SPIE Members Get Free Paper from Digital Library

Lattice Boltzmann numerical simulation and experimental research of dynamic flow in an expansion-contraction microchannel

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