“…Chemical processes are often slow-varying and with normal disturbances, so the application of a fixed model based fault detection and isolation might lead to mistake and fail to report the warning of fault. Huang et al [13] proposed mixture discriminant monitoring, integrating supervised learning and statistical process control charting techniques, which also utilizes both normal adaptive multi-block PCA, adaptive consensus PCA, and adaptive multiscale PCA algorithms for updating the model structure to deal with changing process. Zhao and Sun [15] presented relative PCA and multiple time region based fault reconstruction modeling algorithms for fault subspace extraction and online fault diagnosis.…”