Mixture toxicity of copper and nonylphenol on the embryo-larval development of Rhinella arenarum

Aronzon, Carolina Mariel; Peluso, Julieta; Coll, Cristina Silvia Pérez

doi:10.1007/s11356-020-07857-7

Cited by 14 publications

(9 citation statements)

References 45 publications

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“…Industries and households, via wastewater effluents or runoff, constitute major sources of complex pollution to aquatic recipients (Chen et al 2020 ; Ellis and Butler 2015 ; López-Pacheco et al 2019 ). Although separate pollutants in, e.g., treated wastewater often occur at low concentrations (Farkas et al 2020 ; Vareda et al 2019 ; Wang et al 2018 ), they may interact and contribute to additive or synergistic biological effects when in mixtures, causing adverse effects in exposed organisms (Aronzon et al 2020 ; Cedergreen 2014 ; Mebane et al 2020 ; Wang et al 2019 ). Therefore, in anthropogenic mixtures, such as wastewater effluents, with few conspicuous chemical parameters or without prior knowledge of the chemical composition, general biomarkers of chemical stress might be useful for detection of sublethal mixture toxicity.…”

Section: Introductionmentioning

confidence: 99%

Molecular biomarker responses in the freshwater mussel Anodonta anatina exposed to an industrial wastewater effluent

Ugge

Jonsson

Berglund

2021

Environ Sci Pollut Res

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Using a selection of molecular biomarkers, we evaluated responses in freshwater mussels (Anodonta anatina) exposed to effluent from an industrial wastewater treatment facility. The aims of this work were to (1) assess biomarkers of general toxicity under sublethal exposure to an anthropogenic mixture of chemicals, represented by an arbitrary effluent, and (2) evaluate the potential of A. anatina as a bioindicator of pollution. Adult mussels (n = in total 32; 24 males and 8 females) were exposed (96 h) in the laboratory to a fixed dilution of effluent or to a control treatment of standardized freshwater. Metal concentrations were in general higher in the effluent, by an order of magnitude or more, compared to the control. Toxic unit estimates were used as proxies of chemical stress, and Cu, Ni, and Zn were identified as potential major contributors (Cu> Ni > Zn). Six transcriptional (cat, gst, hsp70, hsp90, mt, sod) and two biochemical (AChE, GST) biomarkers were analyzed in two tissues, gills, and digestive glands. Out of the 16 responses (eight biomarkers × two tissues), 14 effect sizes were small (within ± 28 % of control) and differences non-significant (p > 0.05). Results did however show that (1) AChE activity increased by 40% in gills of exposed mussels compared to control, (2) hsp90 expression was 100% higher in exposed female gills compared to control, and (3) three marker signals (AChE in both tissues, and hsp70 in gills) differed between sexes, independent of treatment. Results highlight a need for further investigation of molecular biomarker variability and robustness in A. anatina.

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Section: Introductionmentioning

confidence: 99%

Molecular biomarker responses in the freshwater mussel Anodonta anatina exposed to an industrial wastewater effluent

Ugge

Jonsson

Berglund

2021

Environ Sci Pollut Res

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“…It should be noted that potentiation and synergy among environmental stressors have been frequently observed ( Koterov et al., 1997 ; Dergacheva et al., 1997 ; Sharetsky et al., 1997 ; Altenburger et al., 2003 ; Geras'kin et al., 2005 ; Barantseva et al., 2009 ; Komarova, 2009 ; Mirzoev, 2010 ; Nagai and Schamphelaere, 2016 ; Versieren et al., 2016 ; Deruytter et al., 2017 ; Aronzon et al., 2020 ; Isaza et al., 2020 ), but very rarely have they been studied under realistic conditions ( Korsakov et al., 2015 ). Most studies are conducted in animal experiments with massive, highly unrealistic radiation exposures (of the order of 0.5–1 Gy or more), and no less massive exposures to chemicals (tens and hundreds of maximum permissible concentrations and doses) ( Koterov et al., 1997 ; Dergacheva et al., 1997 ; Sharetsky et al., 1997 ; Geras'kin et al., 2005 ; Barantseva et al., 2009 ; Komarova, 2009 ; Mirzoev, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

De novo congenital malformation frequencies in children from the Bryansk region following the Chernobyl disaster (2000–2017)

Geger

Lagerev

Pugach

et al. 2020

Heliyon

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Background Ionizing radiation and chemical pollution can disrupt normal embryonic development and lead to congenital malformations and fetal death. We used official government statistical data for 2000–2017 to test the hypothesis that radioactive and chemical pollutants influenced the frequency of de novo congenital malformations in newborns of the Bryansk region of southwest Russia. Methods A variety of statistical approaches were used to assess congenital malformation frequencies including the Shapiro-Wilk test, White's homoscedasticity test, Wilcoxon T-test, Spearman's rank correlation test, and the inversely proportional regression. Results We found that the frequency of polydactyly, multiple congenital malformations, and the frequency of de novo congenital malformations in newborns were significantly higher (p = 0.001–0.054) in regions with elevated radioactive, chemical and combined contamination. Polydactyly, multiple congenital malformations, and the sum of all congenital malformations were 4.7–7.4 times, 2.5–6.8 times, and 3.5–4.6 times higher in contaminated regions in comparison with the control group. The combination of both radioactive and chemical pollutants led to significantly higher frequencies of multiple congenital malformations when compared to regions with only one pollutant (radiation alone: 2.2 times, p = 0.034; chemical pollutants alone: 1.9 times, p = 0.008) implying that the effects of these stressors were at minimum additive. Although there was a trend for decreasing frequencies of multiple congenital malformations during the 2000–2017 period in areas of combined pollution, the opposite was true for regions with radioactive or chemical pollutants alone. However, overall, our models suggest that the frequency of multiple congenital malformations in areas of combined pollution will significantly (p = 0.027) exceed the frequencies observed for regions containing radioactive or chemical pollutants alone by 39.6% and 45.7% respectively, by 2018–2023. Conclusion These findings suggest additive and potentially synergistic effects of radioactive and chemical pollutants on the frequencies of multiple congenital malformations in the Bryansk region of southwestern Russia.

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“…The co-existence of other pollutants may increase or decrease the toxicity of alkylphenols to aquatic species. The equitoxic mixture of copper and nonylphenol was antagonistic to the embryos and larvae of Rhinella arenarum toad at LC50 (Aronzon et al 2020). Carnevali et al (2017) demonstrated that dietary intake of bisphenol A, octylphenol, and nonylphenol by juvenile sea bream was antagonistic to its lipid metabolism.…”

Section: Occurrence Fate and Toxicity Of Alkylphenols In The Aquatic Environmentmentioning

confidence: 99%

Emerging Contaminants: Analysis, Aquatic Compartments and Water Pollution

Morin‐Crini¹,

Lichtfouse²,

Liu³

et al. 2021

Emerging Contaminants Vol. 1

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Over the past two decades, the presence of so-called emerging contaminants in various environmental compartments around the world, such as water, sediments, soils and atmosphere, and in a wide variety of consumer products has become a major concern for society, public health authorities, industry (namely food industry and water sector) and the agricultural sector. Some of these substances are endocrine disruptors and others are proven carcinogens and mutagens. In particular,

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Mixture toxicity of copper and nonylphenol on the embryo-larval development of Rhinella arenarum

Cited by 14 publications

References 45 publications

Molecular biomarker responses in the freshwater mussel Anodonta anatina exposed to an industrial wastewater effluent

Molecular biomarker responses in the freshwater mussel Anodonta anatina exposed to an industrial wastewater effluent

De novo congenital malformation frequencies in children from the Bryansk region following the Chernobyl disaster (2000–2017)

Emerging Contaminants: Analysis, Aquatic Compartments and Water Pollution

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