Mixture toxicity of six sulfonamides and their two transformation products to green algae Scenedesmus vacuolatus and duckweed Lemna minor

Białk‐Bielińska, Anna; Caban, Magda; Pieczyńska, Aleksandra; Stepnowski, Piotr; Stolte, Stefan

doi:10.1016/j.chemosphere.2017.01.035

Cited by 44 publications

(14 citation statements)

References 40 publications

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“…In the case of antibacterial drugs, studies on sulfonamides confirm the abovementioned concerns, reporting lower biological activity of TPs in most cases, however with some exceptions, e.g. TP of sulfanilamide was found to elicit similar toxicity towards algae and aquatic plants as its parent compounds (Isidori et al 2005a;Kim et al 2007;García-Galán et al 2008;Białk-Bielińska et al 2017). Studies on NSAIDs, such as diclofenac (DIC), show a higher toxicity of its TPs towards algae (Lonappan et al 2016), but no acute toxicity towards marine bacteria and crustaceans (Osorio et al 2016;Ma et al 2017).…”

Section: Introductionmentioning

confidence: 85%

Ecotoxicity screening evaluation of selected pharmaceuticals and their transformation products towards various organisms

Grabarczyk

Mulkiewicz

Stolte

et al. 2020

Environ Sci Pollut Res

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The intensive development of medical science has led to an increase in the availability and use of pharmaceutical products. However, nowadays, most of scientific attention has been paid to the native forms of pharmaceuticals, while the transformation products (TPs) of these substances, understood herein as metabolites, degradation products, and selected enantiomers, remain largely unexplored in terms of their characterization, presence, fate and effects within the natural environment. Therefore, the main aim of this study was to evaluate the toxicity of seven native compounds belonging to different therapeutic groups (nonsteroidal anti-inflammatory drugs, opioid analgesics, beta-blockers, antibacterial and anti-epileptic drugs), along with the toxicity of their 13 most important TPs. For this purpose, an ecotoxicological test battery, consisting of five organisms of different biological organization was used. The obtained data shows that, in general, the toxicity of TPs to the tested organisms was similar or lower compared to their parent compounds. However, for example, significantly higher toxicity of the R form of ibuprofen to algae and duckweed, as well as a higher toxicity of the R form of naproxen to luminescent bacteria, was observed, proving that the risk associated with the presence of drug TPs in the environment should not be neglected.

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Section: Introductionmentioning

confidence: 85%

Ecotoxicity screening evaluation of selected pharmaceuticals and their transformation products towards various organisms

Grabarczyk

Mulkiewicz

Stolte

et al. 2020

Environ Sci Pollut Res

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“…However, the addition of antibiotics in livestock and poultry farming can affect the anaerobic digestion process significantly [4]. As a broad-spectrum antibiotic, sulfonamide antibiotics (SAs) are often used in disease prevention and treatment in livestock and poultry industry [5]. With the increasing consumption of SAs, more and more attention has been paid to their effects on anaerobic digestion.…”

Section: Introductionmentioning

confidence: 99%

Effects of sulfonamide antibiotics on digestion performance and microbial community during swine manure anaerobic digestion

Wang

Yuan

et al. 2020

Environmental Engineering Research

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The effects of four types of sulfonamide antibiotics (SAs), including sulfaquinoxaline, sulfamethoxazole, sulfamethoxydiazine and sulfathiazole, on the digestion performance during anaerobic digestion process were studied using a lab-scale anaerobic sequencing batch reactor, and the changes of the community structure in the presence of SAs were investigated with the help of high throughput sequencing. The results indicated that when SAs were added, the hydrolytic acidification process was inhibited, and the accumulation of volatile fatty acids (VFAs) was induced, resulting in the suppression of methane production. However, the inhibition mechanism of different SAs was quite different. The inhibitory effect of high concentration of SAs on the hydrolysis of solid particulate matter into dissolved organic matter followed the order of sulfaquinoxaline > sulfamethoxydiazine > sulfathiazole > sulfamethoxazole. SAs have obvious inhibitory effects on acidification and methanation of dissolved organic matter, especially sulfathiazole. The richness and the community composition of the microorganism including bacteria and archaea in the digestion system were affected by SAs. Under the effect of SAs, the relative abundance of many microorganisms is negatively correlated with methane production, among which Methanobrevibacter, a kind of Archaea, had the greatest influence on methane production.

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“…Levofloxacin is a third‐generation fluoroquinolone antibiotic with a broad spectrum of activity, and it is mainly used in human and veterinary medicine for the therapy of respiratory, soft tissue, and skin infections . With the extensive use of levofloxacin antibiotics, the residual antibiotics may lead to an increase in the bacterial resistance and cause harm to the ecological environment . Therefore, it is extremely important to effectively detect levofloxacin antibiotics in environmental samples.…”

Section: Introductionmentioning

confidence: 99%

One‐step polymerization of hydrophilic ionic liquid imprinted polymer in water for selective separation and detection of levofloxacin from environmental matrices

Zhu

Wang

et al. 2019

J of Separation Science

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A novel green hydrophilic levofloxacin imprinted polymer was presented via onestep polymerization in water using ionic liquid 1,6-hexa-3,3 ′ -bis-1-vinylimidazolium bromine with multiple hydrophilic groups and 2-hydroxyethyl methacrylate as a cofunctional monomer. Adsorption experiment revealed that the ionic liquid significantly improved the water compatible of imprinted polymer, and the excellent recognition of molecularly imprinted polymer for levofloxacin in water corresponds to the synergetic effect of H-bonding and the electrostatic and π-π interactions between the levofloxacin and co-functional monomer. Furthermore, the adsorption process of the imprinted material towards levofloxacin fitted the Langmuir model, and the maximum binding amount of levofloxacin onto the imprinted and corresponding non-imprinted polymer were 16.45 and 6.82 mg/g at 25 • C, respectively. After optimizing the parameters affecting solid phase extraction performance, an enrichment and determination system was achieved to separate and detect levofloxacin from water and sediment samples with recoveries that ranged from 83.67 to 101.33% and relative standard deviation of less than 5.59%. K E Y W O R D Sionic liquids, levofloxacin, molecularly imprinted polymers, water

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Mixture toxicity of six sulfonamides and their two transformation products to green algae Scenedesmus vacuolatus and duckweed Lemna minor

Cited by 44 publications

References 40 publications

Ecotoxicity screening evaluation of selected pharmaceuticals and their transformation products towards various organisms

Ecotoxicity screening evaluation of selected pharmaceuticals and their transformation products towards various organisms

Effects of sulfonamide antibiotics on digestion performance and microbial community during swine manure anaerobic digestion

One‐step polymerization of hydrophilic ionic liquid imprinted polymer in water for selective separation and detection of levofloxacin from environmental matrices

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