Mixtures of Ascorbyl-stearate and Vitamin D3: A Monolayer Study at the Gas/Water Interface

Alkyl esters of l-ascorbic acid: Stability, surface behaviour and interaction with phospholipid monolayers

“…A 40 mM solution of ASC 16 was analysed using 1 H, 13 C, and HSQC-DEPT NMR experiments (Figs. S4-S6) along a period of 30 days.…”

“…The physicochemical behaviour of ASC n has been extensively studied in drug/water systems [2,3,11], but only a few studies have investigated the surface behaviour of these amphiphiles comprising early studies on ascorbyl stearate [12][13][14] and more recently about ascorbyl palmitate (ASC 16 ) [15,16]. Whilst Langmuir monolayers at the air/water interface composed of ascorbyl stearate shows a completely condensed behaviour in the whole surface pressure range, the commercial product ASC 16 forms monolayers which undergo phase transition from a liquid-expanded (LE) to a liquid-condensed (LC) or crystalline phase (C), depending on the electrostatic properties of the film conferred by ionic strength and subphase pH [16,17].…”

Phase Behavior of Ascorbyl Palmitate Coagels Loaded with Oligonucleotides as a New Carrier for Vaccine Adjuvants

“…On cooling these water dispersions form coagels (Coa) [2,6]. The ''coagels'' are hydrated crystalline phases [7][8][9] and their lamellar structure produces at least one highly ordered dimension, so they exhibit sharp X-ray diffraction (XRD) patterns and optical birefringence. Besides, they have been extensively studied as drug delivery systems with potential application in ocular and dermal therapies [9][10][11].…”

Solubilization of Hydrophobic Drugs in Octanoyl‐6‐O‐Ascorbic Acid Micellar Dispersions

“…The presence of one or more hydrophobic chains in vitamin C‐based surfactants leads to the formation of supramolecular self‐assembled aggregates in water, such as micelles, where an inner lipophilic core is surrounded by a hydrophilic shell made up of the polar headgroups. Several different amphiphilic ascorbic acid derivatives have already been produced as esters, ethers, etc., and their physico‐chemical properties reported in the literature 11–14. Assembled in such supramolecular structures, vitamin C derivatives may protect degradable materials (particularly unsaturated fats or vitamins), by confining the lipophilic solutes in the micellar hydrophobic core, while the ascorbic acid polar headgroups face the water phase and efficiently perform their radical‐scavenger activity.…”