MK7924, a Novel Metabolite with Nematocidal Activity from Coronophora gregaria

Kumazawa, Shigenori; Kanda, Mina; Utagawa, Masami; Chiba, Naoko; Ohtani, Hiroyuki; Matsukawa, Takashi

doi:10.7164/antibiotics.56.652

Cited by 13 publications

(4 citation statements)

References 8 publications

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“…The glycosylated polyketide MK7924 (5.72) reported in 2003 from a Thai dead twig-derived Coronophora gregaria L2495 inhibited growth of C. elegans (100 mg mL −1 with unspecied potency). 317 In 1993 clonostachydiol (5.73) was reported from the Indonesian soil-derived Clonostachys cylindrospora FH-A 6607, 318 with subsequent reports in 1997 from an Ethiopian isolate Xylaria obovata ADA-228, 319 in 2006 from a New Zealand marine alga-derived Gliocladium sp., 320 and in 2011 from a Thai isolate Xylaria sp. BCC 21097.…”

Section: Polyketidesmentioning

confidence: 97%

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Natural products as anthelmintics: safeguarding animal health

et al. 2023

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Section: Polyketidesmentioning

confidence: 97%

“…The glycosylated polyketide MK7924 ( 5.72 ) reported in 2003 from a Thai dead twig-derived Coronophora gregaria L2495 inhibited growth of C. elegans (100 μg mL −1 with unspecified potency). 317…”

Section: Fungi (Ascomycota)mentioning

confidence: 99%

Natural products as anthelmintics: safeguarding animal health

et al. 2023

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“…Stereochemical features of small molecules affect their biological performance8-11, but efforts to quantify the roles of such features have been limited. In order to enable a rigorous study of the effects of stereochemistry on biological performance, a collection of small molecules containing systematic variation of multiple stereocenters is required.…”

Section: Introductionmentioning

confidence: 99%

“…Diversity-oriented organic synthesis (DOS) is a strategy to make compound collections to probe biological systems. − There is a growing interest in making DOS libraries with diverse three-dimensional structures. Stereochemical features of small molecules affect their biological performance, − but efforts to quantify the roles of such features have been limited. To enable a rigorous study of the effects of stereochemistry on biological performance, a collection of small molecules containing systematic variation of multiple stereocenters is required.…”

Section: Introductionmentioning

confidence: 99%

Using Biological Performance Similarity To Inform Disaccharide Library Design

et al. 2009

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Diversity-oriented organic synthesis (DOS) is a strategy to make compound collections to probe biological systems [1][2][3][4][5][6][7] . Designing better DOS libraries requires having methods to assess the consequences of different synthesis decisions on the biological performance of resulting library members 8 . Since we are particularly interested in how stereochemistry affects performance in biological assays, we prepared a disaccharide library containing systematic stereochemical variations, assayed the library for different biological effects, and developed methods to assess the similarity of performance between members across multiple assays. These methods allow us to ask which subsets of stereochemical features best predict similarity in patterns of biological performance between individual members and which features produce the greatest variation of outcomes. We anticipate that the data-analysis approach presented here can be generalized to other sets of biological assays and other chemical descriptors. Methods to assess which structural features of library members produce the greatest similarity in performance for a given set of biological assays should help prioritize synthesis decisions in second-generation library development targeting the underlying cellbiological processes. Methods to assess which structural features of library members produce the greatest variation in performance should help guide decisions about what synthetic methods need to be developed to make optimal small-molecule screening collections.

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