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Коротков, С. М.; Lapin, A. V.

doi:10.1023/a:1026182511897

Cited by 25 publications

(6 citation statements)

References 11 publications

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“…Although there is currently limited understanding of the potential mechanism between maternal exposure to Tl and an increased risk of LBW infants, one possible mechanism is that Tl may exert toxicity by disturbing mitochondrial function ( Bragadin et al 2003 ; Korotkov and Lapin 2003 ). Tl crosses the placenta freely ( Hoffman 2000 ) and may affect mitochondrial function in placenta and fetal tissue, which is critical for embryonic and fetal development and growth ( Lane et al 1998 ).…”

Section: Discussionmentioning

confidence: 99%

A Case–Control Study of Prenatal Thallium Exposure and Low Birth Weight in China

Xia

Zheng

et al. 2016

Environ Health Perspect

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BackgroundThallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited.ObjectivesThis study was designed to evaluate whether prenatal Tl exposure is associated with an increased risk of LBW.MethodsThis case–control study involving 816 study participants (204 LBW cases and 612 matched controls) was conducted in Hubei Province, China, in 2012–2014. Tl concentrations were measured in maternal urine collected at delivery, and associations with LBW were evaluated using conditional logistic regression.ResultsHigher maternal urinary Tl levels were significantly associated with increased risk of LBW [crude odds ratio (OR) = 1.52; 95% CI: 1.00, 2.30 for the highest vs. lowest tertile], and the association was similarly elevated after adjustment for potential confounders (adjusted OR = 1.90; 95% CI: 1.01, 3.58 for the highest vs. lowest tertile). Stratified analyses showed slightly higher risk estimates for LBW associated with higher Tl levels for mothers < 28 years old and for mothers with lower household income; however, there was no statistical evidence of heterogeneity in risk according to maternal age (p for heterogeneity = 0.18) or household income (p for heterogeneity = 0.28).ConclusionTo our knowledge, ours is the first case–control study to investigate the association between prenatal Tl exposure and LBW. The results suggest that prenatal exposure to high levels of Tl may be associated with an increased risk of LBW.CitationXia W, Du X, Zheng T, Zhang B, Li Y, Bassig BA, Zhou A, Wang Y, Xiong C, Li Z, Yao Y, Hu J, Zhou Y, Liu J, Xue W, Ma Y, Pan X, Peng Y, Xu S. 2016. A case–control study of prenatal thallium exposure and low birth weight in China. Environ Health Perspect 124:164–169; http://dx.doi.org/10.1289/ehp.1409202

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Section: Discussionmentioning

confidence: 99%

A Case–Control Study of Prenatal Thallium Exposure and Low Birth Weight in China

Xia

Zheng

et al. 2016

Environ Health Perspect

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“…Some placental factors, including lower placental weight and abnormal placental function, are linked to twin growth discordance. Studies have shown that thallium exposure could affect fetal development through a variety of mechanisms, including disturbing mitochondrial function in the placenta and fetal tissue ( 38 , 39 ), triggering oxidative stress through increasing lipid oxidation ( 40 ), decreasing thyroid hormone levels ( 41 ), and inhibiting enzymes with active sites containing cysteine residues ( 42 ). A population study found that for every 25% increase in cord blood thallium levels in a singleton pregnancy, the mitochondrial mtDNA content of the placenta decreased by 4.88% ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Exposure to heavy metals and trace elements among pregnant women with twins: levels and association with twin growth discordance

Chen,

Zhao,

Zhao

et al. 2024

Front. Public Health

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BackgroundTwin growth discordance is one of the leading causes of perinatal mortality in twin pregnancies. Whether prenatal exposure to heavy metals and trace elements is associated with twin growth discordance has not been studied yet.ObjectiveTo evaluate the prenatal level of heavy metals and trace elements in twin pregnancy and its relationship with twin growth discordance.MethodsThis study involving 60 twin pairs and their mothers was conducted in Zhejiang Province, China, in 2020–2021. The concentration of heavy metals and trace elements in maternal blood, umbilical cord, and placenta were collected at delivery and measured by inductively coupled plasma tandem mass spectrometer. The association of prenatal level with twin growth discordance was evaluated using conditional logistic regression.ResultsHigh levels of heavy metal elements (thallium in maternal blood and umbilical cord blood of larger twins, vanadium in the placenta of larger twins) and trace elements (iodine in the placenta of larger twins) during pregnancy, as well as low levels of heavy metal elements (strontium in the umbilical cord blood of larger twins, strontium and chromium in the umbilical cord blood of smaller twins, strontium in the placenta of larger twins, molybdenum and lead in the placenta of smaller twins and difference of molybdenum in the placenta of twins), are associated with intertwin birthweight discordance. Univariate regression analyses showed a significant effect of gestational age at delivery and eleven trace element data on intertwin birthweight discordance. Multivariable logistic regression analysis with transformed variables as dichotomous risk factors combined with baseline demographic characteristics showed Tl in maternal blood as an independent risk factor. The model constructed by combining Tl in maternal blood (OR = 54.833, 95% CI, 3.839–83.156) with the gestational week (OR = 0.618, 95% CI, 0.463–0.824) had good predictive power for intertwin birthweight discordance (AUC = 0.871). The sensitivity analysis results indicate that the effect of maternal blood thallium on intertwin birthweight discordance is stable and reliable.ConclusionTo our knowledge, ours is the first case–control study to investigate the association between elevated maternal thallium levels before delivery and twin growth discordance.

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“…Thallium toxicity is most often associated with substitution for K + ions by cellular membranes due to similar charge and the negative effects this has on the Na/K pump ( 34 , 35 ). Further research has also shown that thallium can directly affect membrane integrity in multiple organelles, including mitochondria, and bind open sulfyhydrol sites in enzymes ( 36 – 38 ). After its accidental discovery, thallium was used as a pesticide and rodenticide as well as a medical treatment of various ailments until it was banned in the US due to risk of accidental poisoning ( 39 ).…”

Section: Discussionmentioning

confidence: 99%

Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids

Forsythe

Devarasetty

Shupe

et al. 2018

Front. Public Health

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IntroductionEnvironmental toxins, such as lead and other heavy metals, pesticides, and other compounds, represent a significant health concern within the USA and around the world. Even in the twenty-first century, a plethora of cities and towns in the U.S. have suffered from exposures to lead in drinking water or other heavy metals in food or the earth, while there is a high possibility of further places to suffer such exposures in the near future.MethodsWe employed bioengineered 3D human liver and cardiac organoids to screen a panel of environmental toxins (lead, mercury, thallium, and glyphosate), and charted the response of the organoids to these compounds. Liver and cardiac organoids were exposed to lead (10 µM–10 mM), mercury (200 nM–200 µM), thallium (10 nM–10 µM), or glyphosate (25 µM–25 mM) for a duration of 48 h. The impacts of toxin exposure were then assessed by LIVE/DEAD viability and cytotoxicity staining, measuring ATP activity and determining IC50 values, and determining changes in cardiac organoid beating activity.ResultsAs expected, all of the toxins induced toxicity in the organoids. Both ATP and LIVE/DEAD assays showed toxicity in both liver and cardiac organoids. In particular, thallium was the most toxic, with IC50 values of 13.5 and 1.35 µM in liver and cardiac organoids, respectively. Conversely, glyphosate was the least toxic of the four compounds, with IC50 values of 10.53 and 10.85 mM in liver and cardiac organoids, respectively. Additionally, toxins had a negative influence on cardiac organoid beating activity as well. Thallium resulting in the most significant decreases in beating rate, followed by mercury, then glyphosate, and finally, lead. These results suggest that the 3D organoids have significant utility to be deployed in additional toxicity screening applications, and future development of treatments to mitigate exposures.Conclusion3D organoids have significant utility to be deployed in additional toxicity screening applications, such as future development of treatments to mitigate exposures, drug screening, and environmental toxin detection.

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Cited by 25 publications

References 11 publications

A Case–Control Study of Prenatal Thallium Exposure and Low Birth Weight in China

A Case–Control Study of Prenatal Thallium Exposure and Low Birth Weight in China

Exposure to heavy metals and trace elements among pregnant women with twins: levels and association with twin growth discordance

Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids

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