2022
DOI: 10.1016/j.molcel.2022.02.013
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MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape

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Cited by 39 publications
(32 citation statements)
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“…The staggering of transcriptional induction and chromatin opening in our system is reminiscent of embryonic stem cells, where the re-establishment of accessible chromatin following DNA replication was secondary to and dependent on nascent transcription of prospectively ''open'' loci (Stewart-Morgan et al, 2019). Acute oncoprotein depletion has also revealed the staggering of nascent transcription and chromatin accessibility (Olsen et al, 2022;Stengel et al, 2021). Chromatin remodeling is a dynamic process that requires the constant engagement of ATP-dependent chromatin remodeling complexes that exhibit…”
Section: Discussionmentioning
confidence: 93%
“…The staggering of transcriptional induction and chromatin opening in our system is reminiscent of embryonic stem cells, where the re-establishment of accessible chromatin following DNA replication was secondary to and dependent on nascent transcription of prospectively ''open'' loci (Stewart-Morgan et al, 2019). Acute oncoprotein depletion has also revealed the staggering of nascent transcription and chromatin accessibility (Olsen et al, 2022;Stengel et al, 2021). Chromatin remodeling is a dynamic process that requires the constant engagement of ATP-dependent chromatin remodeling complexes that exhibit…”
Section: Discussionmentioning
confidence: 93%
“…Production of MLL-AF9 transduced human CD34+ cells has been described. 78 Human CD34+ cells were isolated from human cord blood (New York Blood Center) using the EasySep™ Human Cord Blood CD34 Positive Selection Kit II (Stemcell Technologies). For pre-enrichment, Lymphoprep (Stemcell Technologies) and SepMate™ columns (Stemcell Technologies) were used.…”
Section: Methodsmentioning
confidence: 99%
“…These regions corre-lated with previously identified MLL-fusion binding sites (Figure S4A). 29,49 All 5703 regions showed co-localization with H3K27ac, which were threefold reduced at 873 and increased at 18 regions. GREAT analysis of the reduced MLL/H3K27ac peaks associated with these regions with 586 peaks at promoter regions (defined as ±1 kb of a transcription start site [TSS]).…”
Section: Dsf Induces Mll-fusion-dependent Dynamic Epigenetic Changesmentioning
confidence: 99%