MLL3/MLL4 enzymatic activity shapes DNA replication timing
Deniz Gökbuget,
Ryan M. Boileau,
Kayla Lenshoek
et al.
Abstract:SUMMARYMammalian genomes are replicated in a precise order during S phase, which is cell-type-specific1–3and correlates with local transcriptional activity2,4–8, chromatin modifications9and chromatin architecture1,10,11,12. However, the causal relationships between these features and the key regulators of DNA replication timing (RT) are largely unknown. Here, machine learning was applied to quantify chromatin features, including epigenetic marks, histone variants and chromatin architectural factors, best predi… Show more
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