We combine Hα emission-line and infrared continuum measurements of two samples of nearby galaxies to derive dust attenuation-corrected star formation rates (SFRs). We use a simple energy balance based method that has been applied previously to HII regions in the Spitzer Infrared Nearby Galaxies Survey (SINGS), and extend the methodology to integrated measurements of galaxies. We find that our composite Hα + IR based SFRs are in excellent agreement with attenuation-corrected SFRs derived from integrated spectrophotometry, over the full range of SFRs (0.01 -80 M ⊙ yr −1 ) and attenuations (0 -2.5 mag) studied. We find that the combination of Hα and total infrared luminosities provides the most robust SFR measurements, but combinations of Hα measurements with monochromatic luminosities at 24 µm and 8 µm perform nearly as well. The calibrations differ significantly from those obtained for HII regions (Calzetti et al. 2007), with the difference attributable to a more evolved population of stars heating the dust. Our results are consistent with a significant component of diffuse dust (the 'IR cirrus' component) that is heated by a non-star-forming -2population. The same methodology can be applied to [O II]λ3727 emissionline measurements, and the radio continuum fluxes of galaxies can be applied in place of IR fluxes when the latter are not available. We assess the precision and systematic reliability of all of these composite methods.-4 -The advent of large sets of multi-wavelength observations of nearby galaxies now provides us with the opportunity to derive attenuation-corrected Hα and UV continuum luminosities of galaxies by combining these fluxes with various components of the IR emission. Moreover the availability of integrated optical spectra (and in some cases Pa α maps) of the same galaxies allows us to derive additional attenuation estimates, and test the precision and systematic reliability of the respective attenuation-corrected SFR measurements.The Spitzer Infrared Nearby Galaxies Survey (SINGS; Kennicutt et al. 2003) offers an ideal dataset for testing and calibrating such multi-wavelength SFR estimators. The survey includes imaging of a diverse sample of 75 galaxies within 30 Mpc, with wavelength coverage extending from the UV to the radio, including ultraviolet imaging at 150 and 230 nm, Hα, and 7 infrared wavelengths over 3.6 -160 µm. In addition, drift-scanned spectra over the wavelength range 3600 -6900Å are available, which complement matching infrared spectra over the range 10 -40 µm. We first applied these data to calibrate and test the combined use of Hα and 24 µm infrared fluxes of individual HII regions to derive attenuation-corrected emission-line fluxes (Calzetti et al. 2007, hereafter denoted C07;Kennicutt et al. 2007;Prescott et al. 2007). These studies revealed that the Spitzer 24 µm sources were highly correlated in position and flux with those of optical HII region counterparts. Kennicutt et al. (2007) and C07 found that the ratio of 24 µm to Hα fluxes yielded attenuation-corrected Hα lum...