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Kamernitsky, A. V.; Makeev, G. M.; Vesela, I. V.; Mirsalikhova, N. M.; Turuta, A. M.; Зефиров, Н. С.

doi:10.1023/a:1015716606525

Cited by 1 publication

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“…This discovery fully confirms our concept of biological multifunctionality of steroid hormones, which has been suggested already in 1980. The great majority of the effects, named as rapid nongenomic action, come down to a change in the concentration of Ca 2+ ions inside cell and is certainly D ' 6 D 3-5 ' KAMERNITZKY, LEVINA coordinated with the effect, we have found, of the steroids on the Na + ,K + -dependent ATPase [25][26][27][28], which regulates the inotropic effect.…”

Section: Deblocking Of the Membrane Oxytocin Receptor A Nongenomicmentioning

confidence: 90%

Pregna-D′-pentaranes, Progestins and Antiprogestins: II. Pathways and Realization Mechanisms of Separate Biological Functions of Steroid Hormones

Kamernitzky

Левина

2005

Russ J Bioorg Chem

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The manner in which multifunctional steroid hormones realize their separate biological functions in mammal organisms is considered. This study is carried out on the basis of a systematic set of progesterone analogues, which we developed and described in part I of the review. This set has for the first time enabled the use of compounds of this type for studying the pathways and realization mechanisms of separate biological functions of steroid hormones. The interaction of pregna-D'-pentaranes with the classical progesterone receptor, their independent influence on the myometrium and ovogenesis, and some nonclassical effects are described. A scheme of realization is suggested for the biological functions already known, newly discovered, and presumed by us that, during pregnancy, are fulfilled in mammal organisms by progesterone and its nearest metabolite, dihydroprogesterone.

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Section: Deblocking Of the Membrane Oxytocin Receptor A Nongenomicmentioning

confidence: 90%