Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones

RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis

“…Mad-Max heterodimers compete with Myc-Max heterodimers for the same 'myc box sequence' CAC/TGTG in the Myc-responsive genes (Grandori et al, 2000). RNF17 was able to activate transcription of Mycresponsive genes by recruiting Mad proteins from the nucleus to the cytoplasm (Yin et al, 2001;Yin et al, 1999). In this report, we identify RNF17 as an integral component of the RNF17 granule, a novel nuage in male germ cells.…”

“…As antagonists of Myc, Mad proteins repress transcription of Myc-responsive genes by competing with Myc for binding to the Max transcription factor (Grandori et al, 2000). RNF17 was shown to activate transcription of Mycresponsive genes by retaining Mad proteins in the cytoplasm (Yin et al, 2001;Yin et al, 1999). RNF17 is predominantly cytoplasmic in germ cells.…”

Myc Target in Myeloid Cells-1, a Novel c-Myc Target, Recapitulates Multiple c-Myc Phenotypes

“…After extensive posthybridization washes, filters were exposed to BioMax film at -70°C using a BioMax intensifying screen (Eastman Kodak). cDNA probes for Northern blots have been described previously (14,20,33,34).…”

Characterization of Human Constitutive Photomorphogenesis Protein 1, a RING Finger Ubiquitin Ligase That Interacts with Jun Transcription Factors and Modulates Their Transcriptional Activity

“…Many RING finger proteins have been implicated in regulating transcription through a variety of mechanisms (7), including ubiquitination and degradation of positive (8 -12) or negative regulators of transcription (13)(14)(15). Pathways independent of protein degradation have also been described and may involve protein sumoylation (16), changes in promoter recruitment (17), interference with components of the transcriptional machinery, such as general transcription factors (18,19) or RNA polymerase II (20,21), changes in histone acetylation (22,23), or chromatin rearrangement (24,25).…”