<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Cr</mml:mi></mml:mrow><mml:mprescripts /><mml:mrow /><mml:mrow><mml:mn>52</mml:mn></mml:mrow><mml:mrow /><mml:mrow /></mml:mmultiscripts></mml:mrow></mml:math>(p,n<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mo>)</mml:mo></mml:mrow><mml:mrow><mml:mn>52</mml:mn></mml:mrow></mml:msup></mml:mrow></mml:math>

West, H. I.; Lanier, R.G.; Mustafa, Munshi G.

doi:10.1103/physrevc.35.2067

Cited by 40 publications

(35 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These are directly linked to the calculation of cross sections and thick target yields by means of the activation formula. Additionally the maxima of the excitation functions are not well described in those publications [23,25]. Concerning the production of 51 Mn comprehensive data have been reported by Klein et al [7]" including additional cross section data for 52g,m Mn and the important radioactive by-products 48 V, 48 Cr and 51 Cr.…”

Section: Present Literature and New Experimental Resultsmentioning

confidence: 97%

“…They are also shown in Figs. 2-7 as a function of the proton energy, together with the corresponding literature data [7,[23][24][25][26][27][28][29]. For direct comparison the literature cross section data measured on enriched target materials given in the figures were converted to the natural abundance of the respective chromium isotope (see Table 3).…”

Section: Present Literature and New Experimental Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cross-section measurements for the formation of manganese-52 and its isolation with a non-hazardous eluent

et al. 2013

View full text Add to dashboard Cite

Nuclear reaction / Cross section / Thick target yield / Integral yield / Separation of positron emitter52 Mn / Ion exchange chromatography Summary. With respect to the production of no-carrieradded 52 Mn nuclear reactions on natural chromium were investigated. Cross sections of the reactions nat Cr( p, x) 48 V, 48,49,51 Cr, 52g,m Mn were determined in the proton energy range of 7.6 to 45 MeV. Additionally, production yields of 52g,m Mn and 51 Cr were measured in the energy range from 8.2 to 16.9 MeV and therefrom the calculated saturation thick target yields were obtained as (2.55 ± 0.31), (6.96 ± 0.57), and (1.53 ± 0.15) GBq/μA, respectively.For in vivo applications like PET, low toxicity is critical and sufficient activity of a radiolabelled compound mandatory. Thus, additional purification steps after separation of radionuclides and target materials have to be avoided. However, no isolation procedure has been reported in the literature so far where radiomanganese is directly obtained in a nonhazardous solution. Therefore a new separation procedure was developed utilizing the cation-exchange resin DOWEX 50W×8 (H + -form). 52g Mn was quantitatively isolated from "bulk" chromium after 3 to 4 h in non-hazardous 0.067 M ammonium citrate solution. Up to 99% of 52g Mn activity was harvested within 10 to 15 mL eluent solution with no measureable 51 Cr impurities.

show abstract

Section: Present Literature and New Experimental Resultsmentioning

confidence: 97%

Section: Present Literature and New Experimental Resultsmentioning

confidence: 99%

Cross-section measurements for the formation of manganese-52 and its isolation with a non-hazardous eluent

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The chosen relative errors are 6, 7, 8 and 12% for the above mentioned monitor reactions, respectively. In proton irradiations, the monitor reactions nat Cu(p,x) 62 Zn [24,25], nat Cu(p,x) 63 Zn [25,26], 27 52 Mn [19] were used (cf. [29]).…”

Section: Monitor Reactionsmentioning

confidence: 99%

Investigation of ⁵⁰Cr(d,n)⁵¹Mn and ^natCr(p,x)⁵¹Mn processes with respect to the production of the positron emitter ⁵¹Mn

Klein¹,

Rösch²,

Qaim³

2000

Radiochimica Acta

View full text Add to dashboard Cite

Deuteron and proton induced nuclear reactions / Enriched 50 Cr and nat Cr targets / Positron emitter 51 Mn / Excitation function / Radiochemical separation / Thick target yieldSummary. The positron emitter 51 Mn (t1/ 2 ϭ 46.2 min, Iβϩ ϭ 97%) is of potential interest in positron emission tomography (PET). With a view to optimizing its production route, excitation functions for deuteron induced nuclear reactions on isotopically enriched (ϳ95%) 50 Cr were determined radiochemically over the energy range of 3 to 13 MeV and for proton induced nuclear reactions on nat Cr in the range of 18 to 38 MeV. Cross sections are presented for the reactions: 50 Cr(d,2n) 50m Mn, 50 Cr(d,n) 51 Mn, 50 Cr(d,t) 49 Cr, 50 Cr(d,p) 51 Cr, 50 Cr(d,A) 48 V, 52 Cr(d,2p) 52 V, nat Cr(p,x) 51 Mn, nat Cr(p,x) 52 Mn, nat

show abstract

“…In case of manganese, several radioisotopes are suited because of reasonable half-lives. Production routes have been reported for 56 Mn (2.58 h) [1], 54 Mn (312.2 d) [2,3], 52 Mn (5.6 d) [4,5], 52m Mn (21.1 min) via parent 52 Fe [6], and 51 Mn (46.2 min) [3]. In fact, radiotracers have already been used for labelling contrast agents [7][8][9][10], but due to the limiting physical properties of the nuclides used (long half-life, β − -decay etc.)…”

Section: Introductionmentioning

confidence: 99%

“…While in the case of Gd-compounds the SPECT nuclide 147 Gd (t 1/2 = 38.1 h, E γ = 229 keV (61%)) has been shown to be suitable [11], manganese offers two PET nuclides, namely 52m Mn (t 1/2 = 21.1 min, I β + = 97%, E β + (max) = 0.6 MeV, IT = 1.75%) and 51 Mn (t 1/2 = 46.2 min, I β + = 97%, E β + (max) = 2.5 MeV). 52m Mn of high radionuclidic purity is only available from the 52 Fe/ 52m Mn generator [12][13][14][15][16][17][18][19][20], since direct nuclear reactions, such as the 52 Cr( p, 2n) process, always lead to an isomeric mixture [3,4]. The almost pure positron emitter 51 Mn in comparison has a suitable half-life and can be produced at a small cyclotron in high radionuclidic purity using the 50 Cr(d, n) reaction [3,21].…”

Section: Introductionmentioning

confidence: 99%

Production of the positron emitter ⁵¹Mn via the ⁵⁰Cr(d, n) reaction: targetry and separation of no-carrier-added radiomanganese

Klein¹,

Rösch²,

Coenen³

et al. 2002

Radiochimica Acta

View full text Add to dashboard Cite

Nuclear reaction / Separation of positron emitter 51 Mn / Ion exchange chromatography / Solid phase extraction / Liquid-liquid extraction / Enriched target recoverySummary. In connection with the production of 46.2 min 51 Mn via the 50 Cr(d, n)-process, several separation techniques such as ion exchange chromatography, solid phase extraction, liquid-liquid extraction and co-precipitation have been investigated; the aim was to separate no-carrier-added radiomanganese from the bulk target chromium. Among the separation systems * Mn II /Cr III , * Mn II /Cr VI and * Mn IV /Cr VI , the latter applying the co-precipitation of * Mn IV with Fe III hydroxide was found to be the optimum; the removal of chromium was rapid and quantitative (remaining content < 0.05%) and the separation efficiency was high (99.3% radiochemical yield of * Mn). For production purposes, a sandwiched pellet of the chemical composition Al 4 · 50 CrCl 3 was developed as a new target. This allowed a quick dissolution after irradiation, thus enabling a fast separation of 51 Mn and its production on a MBq scale. A 1 h irradiation at 3 µA (wobbled beam) over an effective deuteron energy range of E d = 12.8 → 7.9 MeV yielded 107 MBq 51 Mn. Simultaneously formed nuclides of other elements, such as 38 Cl, 24 Na, 48 V and 51 Cr were quantitatively separated using the proposed procedure. Only the shorter-lived radioisotope 52m Mn, formed via the 52 Cr(d, 2n) 52m Mn reaction, was present at a low level of 2%, if the enrichment of 50 Cr was 95% (with ∼ 5% 52 Cr).

show abstract

Cr52(p,n)52

Cited by 40 publications

References 32 publications

Cross-section measurements for the formation of manganese-52 and its isolation with a non-hazardous eluent

Cross-section measurements for the formation of manganese-52 and its isolation with a non-hazardous eluent

Investigation of ⁵⁰Cr(d,n)⁵¹Mn and ^natCr(p,x)⁵¹Mn processes with respect to the production of the positron emitter ⁵¹Mn

Production of the positron emitter ⁵¹Mn via the ⁵⁰Cr(d, n) reaction: targetry and separation of no-carrier-added radiomanganese

Contact Info

Product

Resources

About

Cr52(p,n)52

Cited by 40 publications

References 32 publications

Cross-section measurements for the formation of manganese-52 and its isolation with a non-hazardous eluent

Cross-section measurements for the formation of manganese-52 and its isolation with a non-hazardous eluent

Investigation of 50Cr(d,n)51Mn and natCr(p,x)51Mn processes with respect to the production of the positron emitter 51Mn

Production of the positron emitter 51Mn via the 50Cr(d, n) reaction: targetry and separation of no-carrier-added radiomanganese

Contact Info

Product

Resources

About

Investigation of ⁵⁰Cr(d,n)⁵¹Mn and ^natCr(p,x)⁵¹Mn processes with respect to the production of the positron emitter ⁵¹Mn

Production of the positron emitter ⁵¹Mn via the ⁵⁰Cr(d, n) reaction: targetry and separation of no-carrier-added radiomanganese