A weighted difference of the g-factors of the H-and Li-like ions of the same element is theoretically studied and optimized in order to maximize the cancelation of nuclear effects between the two charge states. We show that this weighted difference and its combination for two different elements can be used to extract a value for the fine-structure constant from near-future bound-electron g-factor experiments with an accuracy competitive with or better than the present literature value. PACS numbers: 06.20.Jr, 21.10.Ky, 31.30.jn, 31.15.ac, 32.10.Dk Precision measurements of the free-electron g-factor have enabled determination of the fine-structure constant α to a high accuracy [1, 2]. An independent value of α may be extracted from the measurement of the g-factor of an electron bound in an H-like ion. This can be accomplished by identifying the leading relativistic (Dirac) contribution g D = 2 /3 1 + 2 1 − (Zα) 2 , with Z being the nuclear charge number, after subtracting corrections induced by quantum electrodynamics (QED) and nuclear effects from the measured value. The sensitivity of g D to α is largest for heavy ions. For these ions, however, nuclear effects (charge distributions, polarizabilities etc.) are not well understood and set a limitation on the ultimate accuracy of such determination.In Ref.[3], it was suggested to use a weighted difference of the g-factors of the H-and Li-like charge states of the same element in order to reduce the nuclear size effect by about two orders of magnitude for high-Z ions. In Ref.[4] (see also [5]), a specific weighted difference of the g-factors of heavy H-and B-like ions with the same Z was put forward. It was demonstrated that the theoretical uncertainty of the nuclear size effect in this difference can be brought down to 4 × 10 −10 for heavy ions around Pb, which was several times smaller than the uncertainty due to α at that time. Since then, however, the uncertainty of α was reduced by an order of magnitude [6][7][8], making it more difficult to access α in such experiments. In this Letter we propose a weighted difference of the g-factors of low-Z ions, for which a much stronger cancelation of nuclear effects can be achieved. The low-Z region also seems favorable from the experimental point of view, since experiments so far concentrated in this regime [9][10][11].Measurements of the g-factor of H-like ions have reached the fractional level of accuracy of 3 × 10 −11 [9]. Experiments have also been performed for Li-like ions [10]. In the future, it should be possible to perform experiments not only with a single ion in the trap, but also with several ions simultaneously. Such a setup will directly access differences of g-factors of different ions, greatly reducing systematic uncertainties and possibly gaining two orders of magnitude in accuracy [12]. Such experiments, complemented by corresponding improvements in the theoretical description, would become sensitive to the uncertainty of α.In the present Letter we put forward a method to extract α to higher accura...