Abstract. The longitudinal form factors of the weak vector current of particles with spin J = 1/2 and isospin I = 1/2 are determined by the mass difference and the charge radii of members of the isotopic doublets. The most promising reactions to measure these form factors are the reactions with large momentum transfers involving the spin-1/2 isotopic doublets with a maximum mass splitting. Numerical estimates of longitudinal form factors are given for nucleons and eight nuclear spin-1/2 isotopic doublets.The weak vector current (VC) has the transformation properties of the isotopic triplet. Its 3rd component is associated with the electromagnetic current. The weak VC can be recovered from the electromagnetic current by symmetry considerations. Gerstein and Zeldovich [1] and Feynman and Gell-Mann [2] used isotopic rotation to obtain tensor component of the weak VC in β decay amplitudes. This component is determined by the difference between the anomalous magnetic moments of members of the isotopic doublet.On the mass shell, when the masses of the initial and final states are the same, the vector current of spin J = 1/2 particles is parameterized by two form factors. Off the mass shell the current has a more complex structure. In general, the renormalized vector vertex is described by 12 form factors [3,4]: