Considering the demand for vehicle stability control and the existence of uncertainties in the four-wheel steering (4WS) system, the mixed H2/H∞ robust control methodology of the 4WS system is proposed. Firstly, the linear 2DOF vehicle model, the nonlinear 8DOF vehicle model, the driver model, and the rear wheel electrohydraulic system model were constructed. Secondly, based on the yaw rate tracking strategy, the mixed H2/H∞ controller was designed with the optimized weighting functions to guarantee system performance, robustness, and the robust stability of the 4WS vehicle stability control system. The H∞ method was applied to minimize the effects of modeling uncertainties, sensor noise, and external disturbances on the system outputs, and the H2 method was used to ensure system performance. Finally, numerical simulations based on Matlab/Simulink and hardware-in-the-loop experiments were performed with the proposed control strategy to identify its performance. The simulation and experimental results indicate that the handling stability of the 4WS vehicle is improved by the H2/H∞ controller and that the 4WS system with the H2/H∞ controller has better handling stability and robustness than those of the H∞ controller and the proportional controller.