MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer

Deraz, Elsayed Mohamed; Kudo, Yasusei; Yoshida, Maki; Obayashi, Mariko; Takemoto, Tsunematsu; Tani, Hirotaka; Siriwardena, B. S. M. S.; Kiekhaee, Mohammad Reza; Qi, Guangying; Iizuka, Shinji; Ogawa, Ikuko; Campisi, Giuseppina; Muzio, Lorenzo Lo; Abiko, Yoshimitsu; Kikuchi, Akira; Takata, Takashi

doi:10.1371/journal.pone.0025438

Cited by 83 publications

(90 citation statements)

References 45 publications

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“…MMP9 has also been implicated in the invasion and metastasis of head and neck squamous cell carcinoma (9). Knockout of MMP9 leads to reduced skin and pancreatic carcinogenesis and metastasis, showing delayed tumor vascularization (9)(10)(11). In the present study, the prognostic value of MMP9 in glioma was investigated.…”

Section: Discussionmentioning

confidence: 91%

“…Previous meta-analysis has shown a significant correlation between high expression levels of MMP9 and poor prognosis in gastric cancer (18), breast cancer (19), non-small cell lung cancer (20) and colorectal cancer (21). MMP9 has also been implicated in the invasion and metastasis of head and neck squamous cell carcinoma (9). Knockout of MMP9 leads to reduced skin and pancreatic carcinogenesis and metastasis, showing delayed tumor vascularization (9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

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High expression of MMP9 in glioma affects cell proliferation and is associated with patient survival rates

et al. 2017

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Abstract. Human gliomas are a heterogeneous group of primary malignant brain tumors, which most commonly occur in the central nervous system of children and adults. Previous studies have suggested a prognostic role of matrix metalloproteinase 9 (MMP9) in glioma, however, the frequency and significance of the protein expression of MMP9 in glioma remain to be fully elucidated. In the present study, the expression of MMP9 was detected by reverse transcription-quantitative polymerase chain reaction (qPCR), western blotting and immunohistochemical staining. MTT and colony-forming assays were used to detect the role of MMP9 in the proliferation of glioma cells. MMP9 copy numbers in glioma were examined using qPCR. The results indicated that the expression level of MMP9 was significantly increased in glioma and was associated with World Health Organization (WHO) glioma grades. The high expression of MMP9 in tissues was an independent predictor of survival rates in patients with WHO grade III tumors. The overexpression of MMP9 promoted cell growth and induced a significant increase in clonogenic potential in U87 glioblastoma cell lines. These experimental data suggested that the overexpression of MMP9 in glioblastoma cells may occur primarily through an increase in gene copy number. The results of the present study suggested that the overexpression of MMP9 may be necessary for the transition to the more aggressive phenotype typical of WHO grade III gliomas, suggesting the likely involvement of the MMP9 gene in gliomagenesis and disease progression. IntroductionHuman gliomas are a heterogeneous group of primary malignant brain tumors, which most commonly occur in the central nervous system of children and adults (1). Glioblastoma multiforme (GBM), the most aggressive form of glioma, exhibits advanced features of malignancy, including rapid tumor cell proliferation, apoptosis resistance, florid necrosis and angiogenesis (2). These tumor properties are associated with poor clinical outcome by conferring resistance to chemotherapy and radiotherapy, and by promoting neurological debilitation leading to individuals succumbing to mortality within 12-18 months of diagnosis (3).Gliomas can be categorized based on the type of glial cell, which they are most histologically similar to, the location of the tumor and the aggressiveness of the cancer cells. Tumors, which are most similar to astrocytes are specifically termed astrocytomas and can be further classified into grades I-IV based on the criteria set by the World Health Organization (WHO) (4), with higher grades corresponding to more aggressive tumors. Grade I and II astrocytomas correspond to low-grade tumors, which are predominantly non-malignant. Grade III and IV astrocytomas are high-grade, malignant tumors. Grade III astrocytomas are also known as anaplastic astrocytomas, whereas grade IV astrocytomas, commonly referred to as glioblastoma, are the most aggressive of all gliomas. GBMs are also the most common type of glioma with an annual incident rate of 3.19/100,000 in ...

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

High expression of MMP9 in glioma affects cell proliferation and is associated with patient survival rates

et al. 2017

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“…MMP-10 plays an important role in the invasion and metastasis of head and neck squamous cell carcinoma [41] but its role on breast cancer is largely unknown. We found that MMP-10 expression was decreased in comparison with control suggesting that MMP-10 could act as tumor suppressor.…”

Section: Discussionmentioning

confidence: 99%

Expression of Matrix Metalloproteinases in Human Breast Cancer Tissues

Selvanesan

Somasundaram

Selvi³

et al. 2013

Disease Markers

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Abstract. BACKGROUND:Breast cancer is the most common cancer affecting women in the world today. Matrix metalloproteinases (MMPs) are a family of endopeptidases that can degrade extracellular matrix proteins and promote cell invasion and metastasis. MMPs are differentially expressed and their expressions are often associated with a poor prognosis for patients. OBJECTIVE: The aim of this study is to investigate and compare the expression of MMPs in different grades of human breast cancer tissues with normal breast tissues. PATIENTS AND METHODS: We collected 39 breast cancer samples (24 grade II and 15 grade III) along with 16 normal breast tissues from outside the tumor margin during cancer removal surgery. The samples were analysed for the expression of all known MMPs using real-time quantitative PCR. RESULTS:The results indicate that mRNA expressions of MMP-1, -9,-11,-15,-24 and -25 were upregulated in breast cancer tissues when compared to normal breast tissues. But, the mRNA expressions of MMP-10 and MMP-19 were downregulated in cancer tissue. In membrane associated MMPs like MMP-15 and MMP-24 we found a grade dependent increase of their mRNA expression.CONCLUSION: Our studies demonstrate that MMPs are differentially regulated in breast cancer tissues and they might play various roles in tumor invasion, metastasis and angiogenesis. Thus, MMPs are of immense value to be studied as diagnostic markers and drug target.

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“…64,65 Wingless-type MMTV integration site family member 5B (WNT5B) knockdown suppresses MMP-10 production and invasion indicating that the WNT signaling pathways can also contribute to invasion. 66,67 Transforming growth factor b (TGFb) can be produced by tumor-associated fibroblasts 68 and induce NF-jB activation 69 and SMAD-dependent MMP production, 70 as well as epithelial to mesenchymal transition (EMT) factors, such as Snail and Slug. [71][72][73][74][75][76] Invasion is stimulated by hypoxia in a Notch-dependent fashion.…”

Section: Cell Surface Receptors Influence Invasivementioning

confidence: 99%

“…100,[115][116][117] Although the mechanism is unclear, EMMPRIN homophilic binding induces the expression of a number of proteases, including MMPs, cathepsin B, and urokinase plasminogen activator receptor (uPAR). 100,115,117,118 Other proteases that have been shown to contribute to HNSCC invasion include MMP-10, 66 MMP-13, 80 matriptase, 119 fibroblast activation protein, 120 and uPA/ uPAR, 117,[121][122][123][124] as well as the glycosidase heparanase.…”

mentioning

confidence: 99%

Mechanisms of Invasion in Head and Neck Cancer

Jimenez¹,

Jayakar²,

Ow³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The highly invasive properties demonstrated by head and neck squamous cell carcinoma (HNSCC) are often associated with locoregional recurrence and lymph node metastasis in patients and is a key factor leading to an expected 5-year survival rate of approximately 50% for patients with advanced disease. It is important to understand the features and mediators of HNSCC invasion so that new treatment approaches can be developed.Objectives.-To provide an overview of the characteristics, mediators, and mechanisms of HNSCC invasion.Data Sources.-A literature review of peer-reviewed articles in PubMed on HNSCC invasion.Conclusions.-Histologic features of HNSCC tumors can help predict prognosis and influence clinical treatment decisions. Cell surface receptors, signaling pathways, proteases, invadopodia function, epithelial-mesenchymal transition, microRNAs, and tumor microenvironment are all involved in the regulation of the invasive behavior of HNSCC cells. Identifying effective HNSCC invasion inhibitors has the potential to improve outcomes for patients by reducing the rate of spread and increasing responsiveness to chemoradiation.

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MMP-10/Stromelysin-2 Promotes Invasion of Head and Neck Cancer

Cited by 83 publications

References 45 publications

High expression of MMP9 in glioma affects cell proliferation and is associated with patient survival rates

High expression of MMP9 in glioma affects cell proliferation and is associated with patient survival rates

Expression of Matrix Metalloproteinases in Human Breast Cancer Tissues

Mechanisms of Invasion in Head and Neck Cancer

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