2018
DOI: 10.1002/jcb.27500
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MMP‐11 promotes papillary thyroid cell proliferation and invasion via the NF‐κB pathway

Abstract: Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer, and its incidence is on the rise. It has been reported that some matrix metalloproteinases (MMPs) are abnormally expressed in PTC and can be used as diagnostic markers. However, few studies have explored the underlying mechanisms by which MMPs promote tumor progression. In this study, we used microarray analysis to compare the variations of gene expression within the PTC cell populations and their adjacent normal tissues and found tha… Show more

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Cited by 7 publications
(2 citation statements)
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“…MMPs are a family of enzymes responsible for the degradation of a wide spectrum of extracellular matrix and non-matrix proteins ( 46 ). During carcinogenesis, MMPs can regulate the microenvironment and contribute to several critical steps in cancer development via their involvement in cell proliferation, differentiation, apoptosis, invasion, migration and immune surveillance ( 46 48 ). Thus, upregulated MMP7 expression by B7-H4 may serve an important role in tumor progression.…”
Section: Discussionmentioning
confidence: 99%
“…MMPs are a family of enzymes responsible for the degradation of a wide spectrum of extracellular matrix and non-matrix proteins ( 46 ). During carcinogenesis, MMPs can regulate the microenvironment and contribute to several critical steps in cancer development via their involvement in cell proliferation, differentiation, apoptosis, invasion, migration and immune surveillance ( 46 48 ). Thus, upregulated MMP7 expression by B7-H4 may serve an important role in tumor progression.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, NF-jB has been reported in a number of adenocarcinoma cell lines [53] and NF-jB activity was associated with cancers of the breast [54][55][56][57][58][59][60], ovaries [61,62], endometrium [63], prostate [64][65][66], thyroid [67][68][69][70], pancreas [71][72][73][74], squamous cell carcinoma (SCC) [75,76], esophagus [77][78][79], stomach [80], colorectum [61,[81][82][83], liver [84][85][86], kidneys [87][88][89], bladder [90], lymphoma [91][92][93][94][95], leukemia [96][97][98], multiple myeloma [99][100]…”
Section: Nf-jb and Cancer Nf-jb Association With Precancerous Lesionsmentioning
confidence: 99%