MMP‐2, MMP‐9 and TIMP‐2 gene polymorphisms in Chinese patients with generalized aggressive periodontitis

Abstract

It is suggested that the TIMP2 -418G to C gene polymorphism is associated with G-AgP in the Chinese subjects.

The Role of Immuno-Inflammatory Response in the Pathogenesis of Chronic Periodontitis and Development of Chair-Side Point of Care Diagnostics

“…Total MMP-9 levels and its active form have been demonstrated to significantly increase with periodontal inflammation in comparison to controls, composed of gingivitis and healthy subjects, and to drop along with inflammation after periodontal therapy (Makela et al 1994;Bildt et al 2008) (Figure 1 been able to conclude specific associations with the susceptibility to develop periodontitis or disease severity. Similar allele and genotype frequencies have been demonstrated at the MMP-9 -1562 and -R+279Q polymorphic sites between periodontitis patients and healthy controls, despite the presence of significantly increased protein levels in serum and saliva of diseased subjects (Isaza-Guzman et al ; Loo et al 2011;de Souza et al 2005;Chen et al 2007;Gurkan et al 2008). Nevertheless, the -1572T allele might be associated with a severe form of chronic periodontitis in men (Holla et al 2006).…”

Association of a Functional Polymorphism in the MMP-3 Gene with Moyamoya Disease in the Chinese Han Population

“…The DNA samples were subjected to polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis as described previously [27,28,29]. Briefly, the PCR assay was performed using the established methods in GeneAmp PCR System 9700 (Applied Biosystems).…”

Particular Aspects of Periodontal Disease Pathogenesis

“…Several investigators have evaluated in the recent years the relationship between polymorphisms of genes for MMPs and periodontitis (Astolfi et al 2006;Cao et al 2005;Chen et al 2007;de Souza et al 2003de Souza et al , 2005Gürkan et al 2007Gürkan et al , 2008Holla et al 2004Holla et al , 2005Holla et al , 2006Itagaki et al 2004;Pirhan et al 2008). Due to the limited number of studies carried out to date, it is diffi cult to relate single nucleotide polymorphisms of MMP genes with periodontitis.…”