MMP‐7 affects peritoneal ultrafiltration associated with elevated aquaporin‐1 expression via MAPK/ERK pathway in peritoneal mesothelial cells

Yin, Yue; Zhang, Fen; Zheng, Zhuojun; Xiao, Zhiwen; Yang, Qiaomu; Gong, Nirong; Zhou, Jia; Zuo, Daming; Ai, Jun

doi:10.1111/jcmm.16697

Cited by 4 publications

(5 citation statements)

References 48 publications

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“…However, the expression and role of MMP7 in the dialysate have not been well established. Our previous cross-sectional study had shown that dialysate MMP7 was negatively correlated with UF volume in PD patients [ 19 ]. The reduction of UF volume might be directly related to water retention, leading to the occurrence of CHF.…”

Section: Discussionmentioning

confidence: 99%

“…MMP7 is significantly increased and acts as a noninvasive biomarker of prefibrotic signaling in patients with chronic kidney disease [ 17 , 18 ]. Recently, Yin et al found that MMP7 was highly expressed both in the serum and in the fluid discharged after dialysis in PD patients and could upregulate water channel protein—aquaporins 1 (AQP1), thereby enhancing water reabsorption of peritoneal mesothelial cell [ 19 ]. Thus, highly expressed MMP7 in the peritoneal dialysate might be associated with water transport across the peritoneal membrane and may be related to some clinical complications such as CHF.…”

Section: Introductionmentioning

confidence: 99%

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Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study

Xiao

Tian

Zhang

et al. 2023

Mediators of Inflammation

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Background. Matrix metalloproteinase-7 (MMP7) is markedly expressed in patients with chronic kidney disease; its expression in dialysate and role in patients undergoing peritoneal dialysis (PD) have not been well established. Methods. Participants undergoing PD from June 1st, 2015, to June 30th, 2020, were involved and were followed up every 3 months for the first year and every 6 months thereafter until death, PD withdrawal, or the end of the study. Data at each follow-up point were collected and analyzed for the association with congestive heart failure (CHF), PD withdrawal, and combined endpoint. Results. A total of 283 participants were included in this study. During a median follow-up of 21 months, 20 (7%) participants died, 93 (33%) withdrew from PD, and 105 (37%) developed CHF. A significantly increased level of serum and dialysate MMP7 was observed at baseline. Dialysate MMP7 presented a good linearity with serum MMP7. Baseline serum and dialysate MMP7 levels were associated with CHF in multivariable Cox proportional hazards regression models. After categorization, participants with high baseline MMP7 levels had a higher incidence of CHF (42%), and the hazard ratios (95% confidence intervals) were 1.595 (1.023-2.488). Interestingly, participants with higher serum MMP7 levels were trended to use dialysate with higher glucose concentration. However, the ultrafiltration volumes were not significantly increased. Higher MMP7 levels were also positively associated with PD withdrawal and combined endpoint. Conclusions. The expression of MMP7 in serum and dialysate was markedly increased and was tightly associated with the risk of CHF in PD patients. This finding suggests that the measurement of MMP7 may inform strategies for managing CHF at an earlier stage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study

Xiao

Tian

Zhang

et al. 2023

Mediators of Inflammation

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“…For example, animal experiments showed that treating mice with JNK- or ERK-specific inhibitors decreased MMP-7 expression in tumor tissue, suggesting that MMP-7 induction occurs via the activation of JNK and ERK [ 29 ]. In addition, human peritoneal mesothelial cells express MMP-7 molecules via ERK activation [ 30 ]. Stimulating HT-29 cells with IL-1α enhanced their MMP-7 protein secretion via activation of phospho-ERK and phospho-p38 MAPK molecules [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Bacteroides fragilis Enterotoxin Upregulates Matrix Metalloproteinase-7 Expression through MAPK and AP-1 Activation in Intestinal Epithelial Cells, Leading to Syndecan-2 Release

Jeon

Lee

Kim

2021

IJMS

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Bacteroides fragilis enterotoxin (BFT) produced by enterotoxigenic B. fragilis (ETBF) causes colonic inflammation. BFT initially contacts intestinal epithelial cells (IECs) and affects the intestinal barrier. Although molecular components of the gut epithelial barrier such as metalloproteinase-7 (MMP-7) and syndecan-2 are known to be associated with inflammation, little has been reported about MMP-7 expression and syndecan-2 shedding in response to ETBF infection. This study explores the role of BFT in MMP-7 induction and syndecan-2 release in IECs. Stimulating IECs with BFT led to the induction of MMP-7 and the activation of transcription factors such as NF-κB and AP-1. MMP-7 upregulation was not affected by NF-κB, but it was related to AP-1 activation. In BFT-exposed IECs, syndecan-2 release was observed in a time- and concentration-dependent manner. MMP-7 suppression was associated with a reduction in syndecan-2 release. In addition, suppression of ERK, one of the mitogen-activated protein kinases (MAPKs), inhibited AP-1 activity and MMP-7 expression. Furthermore, the suppression of AP-1 and ERK activity was related to the attenuation of syndecan-2 release. These results suggest that a signaling cascade comprising ERK and AP-1 activation in IECs is involved in MMP-7 upregulation and syndecan-2 release during exposure to BFT.

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“…M1 macrophages induced by lipopolysaccharide (LPS) or interferon γ (IFN-γ) have been reported to express elevated levels of TNF-α and matrix metalloproteinase-7 (MMP-7) ( Terri et al, 2021 ). MMP-7 can break down the extracellular matrix by digesting casein, gelatines, fibronectin and proteoglycan ( Yin et al, 2021 ). MMP-7 has also been found to promote pulmonary and renal fibrosis through the facilitation of epithelial mesenchymal transition ( Ke et al, 2017 ).…”

Section: Intercellular Communicationmentioning

confidence: 99%

“…MMP-7 has also been found to promote pulmonary and renal fibrosis through the facilitation of epithelial mesenchymal transition ( Ke et al, 2017 ). Current research only indicates that MMP-7 is associated with the prognosis of peritoneal dialysis ( Yin et al, 2021 ; Xiao et al, 2023 ), and its correlation with peritoneal fibrosis needs further investigation. In addition, it is worth noting that recent evidences point towards an active role of the M1 subtype in the genesis of peritoneal fibrosis ( Terri et al, 2021 ).…”

Section: Intercellular Communicationmentioning

confidence: 99%

Intercellular communication in peritoneal dialysis

Sheng,

Shan,

Dai

et al. 2024

Front. Physiol.

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Long-term peritoneal dialysis (PD) causes structural and functional alterations of the peritoneal membrane. Peritoneal deterioration and fibrosis are multicellular and multimolecular processes. Under stimulation by deleterious factors such as non-biocompatibility of PD solution, various cells in the abdominal cavity show differing characteristics, such as the secretion of different cytokines, varying protein expression levels, and transdifferentiation into other cells. In this review, we discuss the role of various cells in the abdominal cavity and their interactions in the pathogenesis of PD. An in-depth understanding of intercellular communication and inter-organ communication in PD will lead to a better understanding of the pathogenesis of this disease, enabling the development of novel therapeutic targets.

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MMP‐7 affects peritoneal ultrafiltration associated with elevated aquaporin‐1 expression via MAPK/ERK pathway in peritoneal mesothelial cells

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 4 publications

References 48 publications

Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study

Matrix Metalloproteinase-7 Associated with Congestive Heart Failure in Peritoneal Dialysis Patients: A Prospective Cohort Study

Bacteroides fragilis Enterotoxin Upregulates Matrix Metalloproteinase-7 Expression through MAPK and AP-1 Activation in Intestinal Epithelial Cells, Leading to Syndecan-2 Release

Intercellular communication in peritoneal dialysis

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