2019
DOI: 10.1016/j.pathol.2018.10.008
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MMP-9-1562 C/T single nucleotide polymorphism associates with increased MMP-9 level and activity during papillary thyroid carcinoma progression

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Cited by 19 publications
(22 citation statements)
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“…ABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress [ 30 ]. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis [ 31 ]. AKT serine/threonine kinase 2 (AKT2) is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains.…”
Section: Discussionmentioning
confidence: 99%
“…ABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress [ 30 ]. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis [ 31 ]. AKT serine/threonine kinase 2 (AKT2) is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains.…”
Section: Discussionmentioning
confidence: 99%
“…In particular, interleukin-1 has dual roles of anti-tumor and pro-tumor [43]. Positive regulation of MAP kinase activity and metalloendopeptidase activity are thought to be associated with thyroid cancer [44,45]. This is a validation of the major carcinogenic event of PTC is the activation of MAPK.…”
Section: Discussionmentioning
confidence: 99%
“…In the process of degradation, large amounts of vascular endothelial growth factors stored in the extracellular matrix can be released to induce tumor angiogenesis and provide the necessary nutritional basis and pathway for tumor cell invasion [25]. MMP-9, also known as Gelatinase B, can degrade and destroy extracellular matrix and basement membrane near the surface of tumor cells, release a large number of growth promoting factors, and make tumor cells invade the surrounding tissues along the missing basement membrane, promoting the invasion and metastasis of tumor cells [26][27][28].…”
Section: Discussionmentioning
confidence: 99%