MMP-9 Level Comparation between Spontaneous Abortion and Normal Pregnancy

Abstract

BACKGROUND: Abortion remains a problem in the obstetric care as it is one of the causes of maternal and fetal death. Bleeding or miscarriage threat in the first trimester comprises 20% to 25% of all pregnant women, and 50% of them will end as spontaneous abortion. The major cause of maternal death in abortion is hemorrhage. Some recent studies have indicated that MMP-9 is important in the process of embryo implantation into the endometrium and spontaneous abortion occurs when there is an overwhelming increase of MMP-9. This data indicate the importance of a further research to elucidate the role of MMP-9 in spontaneous abortion.METHODS: This was a cross sectional study, included 70 pregnant women with gestational age <20 weeks who came for examination and treatment at the Department of Obstetrics and Gynecology, Medical Faculty of Padjadjaran University/Hasan Sadikin Hospital, Bandung. RESULTS: There were differences in the MMP-9 levels in spontaneous abortion compared to normal pregnancy and MMP-9 had a cut-off point >1221.7 with the sensitivity of 48.6% specificity of 80%, and accuracy of 60.9%.SUMMARY: The MMP-9 level in spontaneous abortion was higher than in normal pregnancy.KEYWORDS: MMP-9, spontaneous abortion, normal pregnancy

MMP-9 and TIMP-1 Promote Extracellular Matrix Remodeling in the Formation of Ovarian Endometrioma: in vitro Study on Chicken Chorioallantoic Membrane

“…(12,13) MMP-2 (Gelatinase A) and MMP-9 (Gelatinase B) are the most significant MMPs in the process of invasion and angiogenesis that specifically degrade collagen type IV as their substrate. (14) These enzymes are regulated by their natural inhibitors, TIMP-1 and TIMP-2, which are also involved in the regulation of angiogenesis. (15,16) The initial formation of endometriosis is preceded by the reflux of endometrial tissue in the pelvic peritoneal cavity, followed by adhesion and invasion on the mesothelium layer through the proteolysis of the ECM.…”