2020
DOI: 10.21203/rs.2.24001/v1
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MMP10 involved in Radiosensitivity in Non-Small Cell Lung Cancer via DNA damage repair pathway

Abstract: Background Non-small cell lung cancer (NSCLC) is an aggressive subtype of lung cancer with high mortality and morbidity. Our purpose in this study is to investigate the effect of MMP10 in NSCLC during radiotherapy and its mechanism. Materials and methods We analyzed MMP10 expression and overall survival rate of patients via UALCAN analysis. Western blot analysis was used to test the protein expression. We applied clonogenic assay and apoptosis assay to detect radioresistance in vitro. The level of DNA damage a… Show more

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