MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population

Wang, Kai; Zhou, Yi; Li, Gang; Wen, Xin-Li; Kou, Yuan; Yu, Jiao; He, Haifeng; Zhao, Qian; Feng, Xue; Wang, Jin; Zhao, Xinhan

doi:10.1038/s41598-018-31664-3

Cited by 26 publications

(23 citation statements)

References 34 publications

(31 reference statements)

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“…Invasion and migration are the main biological characteristics associated with tumor malignancy [35,36]. MMPs and inhibitors of TIMPs play a vital role in the process of degradation of the ECM and basal membrane (BM) which is closely related to tumor invasiveness [37,38].…”

Section: Discussionmentioning

confidence: 99%

TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9

Wang

Xiang

et al. 2019

Cell Adhesion & Migration

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Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression of TIMP-2 and MMP-9 in a CRC tissue microarray by immunohistochemistry. We found that lower TIMP-2 or/and higher MMP-9 expression in cancer tissues was correlated with poorer overall survival (OS). TIMP-2 or MMP-9 expression was independent prognostic factors for CRC. Furthermore, TIMP-2 and MMP-9 expression had a synergistic role as efficient prognostic indicators for CRC patients. In vitro and in vivo, TIMP-2 could inhibit HCT 116 cells invasion and migration by regulating MMP-9. In sum, a combined expression of TIMP-2 and MMP-9 as efficient prognostic indicators was found for the first time.

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Section: Discussionmentioning

confidence: 99%

TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9

Wang

Xiang

et al. 2019

Cell Adhesion & Migration

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“…Polymorphisms in many genes reportedly alter the risk of cancer and are considered potential markers of carcinogenesis. Polymorphisms of matrix metalloproteinase (MMP)8 rs11225394 and MMP9 rs3787268 are closely related to BC risk in the Chinese Han population . The XPG (rs1047768 T > C) mutation may play an important role in the reduction of progression‐free survival and can be used as a predictor of poor prognosis in BC .…”

Section: Discussionmentioning

confidence: 99%

SNP mutation‐related genes in breast cancer for monitoring and prognosis of patients: A study based on the TCGA database

et al. 2019

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Advances in cancer biology have allowed early diagnosis and more comprehensive treatment of breast cancer (BC). However, it remains the most common cause of cancer death in women worldwide because of its strong invasiveness and metastasis. In‐depth study of the molecular pathogenesis of BC and of relevant prognostic markers would improve the quality of life and prognosis of patients. In this study, bioinformatics analysis of SNP‐related data from BC patients provided in the TCGA database revealed that six mutant genes ( NCOR1, GATA3, CDH1, ATM, AKT1, and PTEN ) were significantly associated with the corresponding expression levels of the proteins. The proteins were involved in multiple pathways related to the development of cancer, including the PI3K‐Akt signaling pathway, pertinent microRNAs, and the MAPK signaling pathway. In addition, overall survival and recurrence‐free survival analysis revealed the close associations of the expression of GATA3 , NCOR1 , CDH1, and ATM with survival of BC patients. Therefore, detecting these gene mutations and exploring their corresponding expression could be valuable in predicting the prognosis of patients. The results of the high‐throughput data mining provide important fundamental bioinformatics information and a relevant theoretical basis for further exploring the molecular pathogenesis of BC and assessing the prognosis of patients.

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“…We selected the GoldMag-Mini Whole Blood Genomic DNA Purification Kit (GoldMag Co. Ltd. Xi’an City, China) to extract the DNA from the 5 ml peripheral venous blood; and Nanodrop 2000 (Gene Company Limited) was used to detect the concentration and purity of samples, DNA to ensure that the samples could be used for subsequent experiments. Same as previously published articles [14, 15]. rs2277698, rs2009196, rs7342880, rs11654470, rs2003241, and rs4789936 Six SNPs were selected in our study based on minor allele frequency data more than 0.05 in the global population [16].…”

Section: Methodsmentioning

confidence: 99%

Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

Wang

Huang

et al. 2019

BMC Cancer

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Background TIMP-2 gene plays an important role in the development of breast cancer. The present study was conducted to evaluate whether TIMP-2 gene polymorphisms are associated with breast cancer risk in a Han Chinese cohort. Methods Six single nucleotide polymorphisms (SNPs) within the TIMP-2 gene in 571 breast cancer and 578 healthy control subjects were genotyped through the Agena MassARRAY. Logistic regression analysis was used to assess the influence of TIMP-2 polymorphisms on breast cancer. Functional annotation of TIMP-2 variants and TIMP-2 expression were analyzed by bioinformatics. Results Bioinformatics analysis found that rs4789936 was likely to affect transcription factor binding, motifs, DNase footprint, and DNase peaks; and TIMP-2 was under-expressed in breast cancer, the risk allele of rs4789936 was associated with increased expression of TIMP-2 in peripheral blood samples. Importantly, individuals carrying TIMP-2 rs2277698 T allele have a 19% lower risk of breast cancer than individuals with allele C, providing protection (OR = 0.81, 95%CI = 0.67–0.99, p = 0.041). In the breast cancer patients with c-erb positive and PR positive, when the CC genotype was used as a reference, individuals carrying the TT genotype increased the risk of breast cancer. Haplotype analysis showed “TCC” was associated with a reduced risk of breast cancer (OR = 0.79, 95%CI = 0.63–0.97, p = 0.028). Conclusion Our study indicated that TIMP-2 rs2277698 was associated with breast cancer susceptibility.

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MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population

Cited by 26 publications

References 34 publications

TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9

TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9

SNP mutation‐related genes in breast cancer for monitoring and prognosis of patients: A study based on the TCGA database

Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

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