Mmu-miR-126a-3p plays a role in murine embryo implantation by regulating Itga11

Li, Zhengyu; Jia, Jia; Gou, Jinhai; Tong, Aiping; Liu, Xinyu; Zhao, Xia; Yi, Tao

doi:10.1016/j.rbmo.2015.05.016

Cited by 27 publications

(12 citation statements)

References 36 publications

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“…Based on the present ceRNA networks results and gene ontology analysis in the GSE137445 array dataset, three miRNAs (miR-486, miR-516b-5p and miR-584-3p) binding to both FEZF1-AS1 and ITGA11 were identified. Furthermore, three other miRNAs (miR-126a, miR-29b and miR-145) targeting ITGA11 were selected based on previous reports (29)(30)(31). After miRNA overexpression, miR-516b-5p significantly downregulated FEZF1-AS1 expression ( Fig.…”

Section: Fezf1-as1 Can Compete With Mir-516b-5p For Direct Binding Tomentioning

confidence: 99%

Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis

Song

Ding

et al. 2020

Int J Oncol

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Long non-coding RNAs (lncRNAs) have emerged as key players in the development and progression of cancer. FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) is a novel lncRNA that is involved in the development of cancer and acts as a potential biomarker for cancer. However, the clinical significance and molecular mechanism of FEZF1-AS1 in non-small cell lung cancer (NSCLC) remains uncertain. In the present study, FEZF1-AS1 was selected using Arraystar Human lncRNA microarray and was identified to be upregulated in NSCLC tissues and negatively associated with the overall survival of patients with NSCLC. Loss-of-function assays revealed that FEZF1-AS1 inhibition decreased cell proliferation and migration, and arrested cells at the G 2 /M cell cycle phase. Mechanistically, FEZF1-AS1 expression was influenced by N6-methyladenosine (m 6 A) modification. Since FEZF1-AS1 was mainly located in the cytoplasmic fraction of NSCLC cells, it was hypothesized that it may be involved in competing endogenous RNA regulatory network to impact the prognosis of NSCLC. Via integrating Arraystar Human mRNA microarray data and miRNA bioinformatics analysis, it was revealed that ITGA11 expression was decreased with loss of FEZF1-AS1 and increased with gain of FEZF1-AS1 expression, and microRNA (miR)-516b-5p inhibited the expression levels of both FEZF1-AS and ITGA11. RNA-binding protein immunoprecipitation and RNA pulldown assays further demonstrated that FEZF1-AS1 could bind to miR-516b-5p and that ITGA11 was a direct target of miR-516b-5p by luciferase reporter assay. Overall, the present findings demonstrated that FEZF1-AS1 was upregulated and acted as an oncogene in NSCLC by regulating the ITGA11/miR-516b-5p axis, suggesting that FEZF1-AS1 may be a potential prognostic biomarker and therapeutic target for NSCLC.

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Section: Fezf1-as1 Can Compete With Mir-516b-5p For Direct Binding Tomentioning

confidence: 99%

Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis

Song

Ding

et al. 2020

Int J Oncol

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“…Enhancement of miR-429 resulted in suppression of the migratory and invasive capacities of cells, probably through targeting protocadherin 8, leading to reduced implantation sites [ 28 ]. On the contrary, miR-126-3p was specifically up-regulated in implantation sites, promoting cell migratory and invasive capacity by regulating the expression of integrin α11 [ 29 ]. Moreover, we know that sex hormones induce changes in miRNA expression in the endometrium, for example, progesterone induced the expression of miR-125b in human endometrial epithelium cells.…”

Section: Ncrnas and Embryo Implantationmentioning

confidence: 99%

Non-Coding RNAs in Endometrial Physiopathology

Ferlita

Battaglia

Andronico

et al. 2018

IJMS

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The Human Genome Project led to the discovery that about 80% of our DNA is transcribed in RNA molecules. Only 2% of the human genome is translated into proteins, the rest mostly produces molecules called non-coding RNAs, which are a heterogeneous class of RNAs involved in different steps of gene regulation. They have been classified, according to their length, into small non-coding RNAs and long non-coding RNAs, or to their function, into housekeeping non-coding RNAs and regulatory non-coding RNAs. Their involvement has been widely demonstrated in all cellular processes, as well as their dysregulation in human pathologies. In this review, we discuss the function of non-coding RNAs in endometrial physiology, analysing their involvement in embryo implantation. Moreover, we explore their role in endometrial pathologies such as endometrial cancer, endometriosis and chronic endometritis.

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“…13 These regulatory RNAs are involved in diverse biological processes, and their aberrant expression is associated with various pathological processes and diseases, such as cancer and diabetes. 14 Additionally, miRNAs have been reported to play important roles in cellular proliferation, differentiation, and apoptosis as well as the implantation process. 1 Notably, a number of studies have shown that miRNAs can specifically affect infertility and the human reproductive system, 15 and it has recently been reported that miRNAs can regulate RIF occurrence.…”

Section: Introductionmentioning

confidence: 99%

Association Between miR-605 A>G, miR-608 G>C, miR-631 I>D, miR-938 C>T, and miR-1302-3 C>T Polymorphisms and Risk of Recurrent Implantation Failure

et al. 2019

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Recurrent implantation failure (RIF) is diagnosed when pregnancy failure occurs after 2 consecutive in vitro fertilization-embryo transfers (IVF-ET) to the endometrium using at least 4 high-quality embryos. MicroRNAs (miRNAs) are a class of small noncoding RNA and reported to play an important role in cell proliferation as well as implantation process. Recently, it has been reported that miRNA can regulate RIF occurrence. So, we were to examine the association between the specific miRNA polymorphisms and RIF in Korean women. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay to determine the frequency of the following polymorphisms: miR-605A>G, miR-608G>C, miR-631I>D, miR-938C>T, and miR-1302-3C>T. Our results demonstrate a decreased incidence of RIF in patients with the miR-1302-3C>T polymorphism (adjusted odds ratio [AOR], 0.234; 95% confidence interval [CI], 0.089-0.618; P = .003). Based on our allele combination analysis, the C-T ( miR-938/ miR-1302-3: OR = 0.259; 95% CI, 0.100-0.674; P = .003) allele was also associated with decreased RIF risk. From our interaction analysis with miR-1302-3, the miR-1302-3CC genotype (AOR = 43.332; 95% CI, 5.576-336.745) showed an association with RIF prevalence in participants with an activated partial thromboplastin time (aPTT) ≤22.6. We found that the miR-1302-3C>T polymorphism is significantly associated with RIF development in Korean women. Specifically, our study suggests that the T allele of miR-1302-3 may decrease the risk of RIF in Korean women.

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Mmu-miR-126a-3p plays a role in murine embryo implantation by regulating Itga11

Cited by 27 publications

References 36 publications

Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis

Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis

Non-Coding RNAs in Endometrial Physiopathology

Association Between miR-605 A>G, miR-608 G>C, miR-631 I>D, miR-938 C>T, and miR-1302-3 C>T Polymorphisms and Risk of Recurrent Implantation Failure

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