The MMX Rover, developed by CNES and DLR, will fly to and explore the surface of the Martian Moon Phobos within the JAXA Martian Moon Exploration Mission. It will be the first wheeled locomotion system in a milli-g environment. In the development of the rover, simulations have been used to test and develop its robotic activities. This paper presents the multi-physics simulations that are being used. The overall simulator setup and its main components are discussed. To provide appropriate simulations for the various topics while maintaining a unified simulator, a modular approach was required. The different modules and their role will be outlined. For this, Dymola's implementation of the Modelica modeling language provides the basis, especially regarding multi-body dynamics, and the possibility to include external libraries, e. g. for environment interaction, control logic and visualization. Finally, examples for the simulator used in driving, uprighting, alignment and separation will be presented. These examples illustrate the approach on experiment design, setup and result evaluation. To date the MMX Rover simulator is regarded as an indispensable development and analysis tools, especially since representative lab experiments are much limited when designing a robotic system for milli-g operations. It is also planned to be used during operations phase for planning and analysis.