Mn(III), Zn(II) and Pt(II) macroacyclic complexes: Synthesis, X-ray structures, anticancer and antioxidant activities

Keypour, Hassan; Ansari, Neda; Mahmoudabadi, Masoumeh; Karamian, Roya; Farida, Seyed Hamed Moazzami; Moghadam, Mahboube Eslami; Gable, Robert W.

doi:10.1016/j.ica.2020.119705

Cited by 17 publications

(8 citation statements)

References 30 publications

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“…Müller further stated that crystal structure could be determined at more than one temperature, because occasionally the crystal packing varies as a function of temperature, and this variation is seldom accompanied by noticeable crystal cracking [86]. In line with Müller's further statement, none of the six crystallographic studies reported using more than one temperature [75,[78][79][80][81][82]87].…”

Section: Crystallographic Studiesmentioning

confidence: 86%

“…However, for the few cases when direct methods fail, Patterson methods might suitably work particularly with a few heavier atoms in the molecule. In line with Müller's statements on structure solution, none of the six crystallographic studies reported the use of Patterson method [75,[78][79][80][81][82]87]. However, Damercheli et al used SIR2004 program, while the other five crystallographic studies reported the use of direct method of SHELXS for structures "solutions on the diffracted manganese complexes" crystals [75,[78][79][80][81][82].…”

Section: Absorption Correctionmentioning

confidence: 94%

“…Anisotropic displacement parameters were used to refine the nonhydrogen atoms, while all hydrogen atoms were placed at geometrical estimates and refined using the riding model. Concisely, five researchers among the six researchers on crystallographic studies used graphite-monochromated Mo-Kα radiation (λ � 0.71073˚A), while Keypour et al were the only group of researchers who used mirror-monochromated Cu-Kα radiation (λ � 1.54184 Å) [75,[78][79][80][81][82].…”

Section: Damercheli Et Al's Crystallographic Activitymentioning

confidence: 99%

“…Müller defined structure refinement as a process of iterative variation of the molecular model aimed at maximizing its agreement with the diffraction data [87]. All the six crystallographic studies reported the use of full-matrix least-square methods based on F2 for structure refinements [75,[78][79][80][81][82]. All the nonhydrogen atoms on F2 were anisotropically refined anisotropic thermal parameters using SHELXL software package program, while the hydrogen atoms in the crystals of the Mn complexes were all located from difference Fourier maps, and residual hydrogen atoms were fixed with thermal parameters and placed at geometrical positions.…”

Section: Absorption Correctionmentioning

confidence: 99%

“…All the nonhydrogen atoms on F2 were anisotropically refined anisotropic thermal parameters using SHELXL software package program, while the hydrogen atoms in the crystals of the Mn complexes were all located from difference Fourier maps, and residual hydrogen atoms were fixed with thermal parameters and placed at geometrical positions. Damercheli et al, Seck et al, and Keypour et al further stated the use of riding model to refine the hydrogen atoms at the geometrical positions [78,80,82].…”

Section: Absorption Correctionmentioning

confidence: 99%

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Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Odularu

2022

Journal of Chemistry

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Choice of ligands is significant to successful synthesis of metal complexes (coordination compounds). This study reports the use of Schiff base as the right ligand to control the poor bioavailability and neurodegenerative toxicity challenges of manganese ion. In line with this study, document analysis was used as the methodological approach to evaluate the significance of Schiff base ligands in easing these manganese’s challenges and aligning the resultant coordination compounds (manganese Schiff base complexes) as therapeutic agents in anticancer studies. Report also involves crystallographic studies where single crystal X-ray crystallography was used as a chemical characterization technique. In addition, molecular docking studies, MOE2008, and AutoDock software were used to reveal the mode of interaction between the Schiff base and the manganese(II) and (III) ions, as well as scrutinizing the biological efficacy of the manganese(II) and manganese(III) Schiff bases coordination compounds as anticancer agents against some anticancer cell lines. Conclusion drawn was that manganese(II) and manganese(III) Schiff bases coordination compounds gave more active and potent activities than the corresponding Schiff bases. As a result, challenges of neurodegenerative toxicity and poor bioavailability of manganese ion were overcome, and the chelation therapy was fulfilled. Results from single crystal X-ray crystallography confirmed the successful synthesis of manganese(II) and manganese(III) Schiff bases coordination compounds and revealed the mechanism of reaction, while the molecular docking buttressed the biological activities of the Schiff base ligand and manganese Schiff base coordination compounds by portraying the structure activity relationship (SAR) between either Schiff base or the manganese Schiff base coordination compounds and the virtual cancer cell line (receptor protein), where hits were obtained for lead optimizations.

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Section: Crystallographic Studiesmentioning

confidence: 86%

Section: Absorption Correctionmentioning

confidence: 94%

Section: Damercheli Et Al's Crystallographic Activitymentioning

confidence: 99%

Section: Absorption Correctionmentioning

confidence: 99%

Section: Absorption Correctionmentioning

confidence: 99%

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Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Odularu

2022

Journal of Chemistry

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A series of nanoscaled Pt(0)‐phosphorus ylide complexes based on [60]fullerene: Synthesis, characterization, and in vitro biological assessments

Yousefi

Sabounchei

Farida

et al. 2021

Applied Organom Chemis

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Herein, A type of Pt(0) complexes based on fullerene C 60 including phosphorus ylides as monodentate ligands, [(η 2 -C 60 )Pt(Y 1-4 ) 2 ] (Y), were synthesized via adding of related monodentate phosphorus ylide to toluene solution of C 60 and Pt (dba) 2 (dba = dibenzylideneacetone). The structures were identified using IR, NMR ( 1 H, 13 C, and 31 P), UV-visible, ESI-MS, and EDX spectroscopies, thermal curve TGA, and electron microscopic images (scanning electron microscopy, SEM, and transmission electron microscopy, TEM). The molecular structure of complexes clearly shows that two ylidic ligands in a cis configuration and two hexagons of C 60 in the junction [6,6] coordinate to Pt(0) metal center. These complexes were treated as biological agents in antibacterial, antioxidant, and anticancer assessments. Three Gram-negative (Escherichia coli, Salmonella typhimurium, and Shigella dysenteriae) and three Gram-positive bacteria (Bacillus subtilis, Bacillus cereus, and Staphylococcus aureus) were used for antibacterial investigation. The activities of complexes against cancer cells were also tested using AGS (gastric carcinoma), A549 (non-small lung carcinoma), and MCF-7 (breast carcinoma) cell lines. All biological studies on synthesized nanocomplexes showed promising effects in comparison with standards.antibacterial and antioxidant investigation, anticancer activity, fullerene C 60 , phosphorus ylide, platinum nanocomplexes | INTRODUCTIONDespite the significant recent gains in medical treatments, cancer, mostly treated by surgery, chemotherapy, and radiotherapy, is still the second leading cause of death globally. [1] There is still a long challenging way to

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Bleomycin‐dependent DNA damage, erythrocyte hemolysis, antitumor MTT assay, and antimicrobial activity studies for Cd (II), Mn (II), Zn (II), Cr (III), and Fe (III) complexes of a multidentate carbohydrazone ligand

Abou El‐Reash,

Al‐Farraj,

Adam

et al. 2024

Applied Organom Chemis

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Cd (II), Mn (II), Zn (II), Cr (III), and Fe (III) complexes of a carbohydrazone ligand H4EBC, prepared by the reaction of ethyl acetate and carbohydrazide, have been prepared and fully characterized. The ligand H4EBC acted as a bidentate carbohydrazone with Cd (II) and coordinated through the nitrogen of both (‐NH) and (C=N)azomethine groups, while with Mn (II) and Zn (II), it acted as a neutral NN bidentate ligand. In complexes with Fe (III) and Cr (III), H4EBC acts a bi‐negative tetra‐dentate, coordinating through the oxygen atoms of both enolized (C=O)ester groups and the nitrogen of both (C=N)azomethine groups. To illustrate the proposed geometries and chemical reactivity of the compounds, we employed DFT calculations. Additionally, thermal studies provided insights into the stability of the isolated compounds. Interestingly, the prepared complexes demonstrated emission broad bands at various wavelengths, indicating ligand to metal charge transfer. Based on the inhibition of DNA destruction, the complexes can be ranked in the following order: [Cd(H4EBC)Cl2].2H2O] (1) > H4EBC > [Mn(H4EBC)Cl2)].(H2O)2] (2) > [Zn(H4EBC)Cl2].2H2O] (3) > [Fe(H2EBC)Cl(H2O)].H2O (5) > [Cr(H2EBC)Cl (H2O)].H2O (4). Regarding erythrocyte hemolysis, the order of effectiveness can be arranged as follows: (2) > (1) > H4EBC > (5) > (3) > (4). We further investigated the compounds for their potential in antitumor activity against two cell lines and antimicrobial behavior.

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Mn(III), Zn(II) and Pt(II) macroacyclic complexes: Synthesis, X-ray structures, anticancer and antioxidant activities

Cited by 17 publications

References 30 publications

Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

Manganese Schiff Base Complexes, Crystallographic Studies, Anticancer Activities, and Molecular Docking

A series of nanoscaled Pt(0)‐phosphorus ylide complexes based on [60]fullerene: Synthesis, characterization, and in vitro biological assessments

Bleomycin‐dependent DNA damage, erythrocyte hemolysis, antitumor MTT assay, and antimicrobial activity studies for Cd (II), Mn (II), Zn (II), Cr (III), and Fe (III) complexes of a multidentate carbohydrazone ligand

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