Mn-modified HfO2 nanoparticles with enhanced photocatalytic activity

González, L.; Gálvez-Barboza, Saúl; Vento-Lujano, Efrain; Rodríguez-Galicia, José L.; Garcı́a-Cerda, L.A.

doi:10.1016/j.ceramint.2020.02.130

Cited by 20 publications

(7 citation statements)

References 29 publications

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“…In our study, ROS amplification for comparable surface exposures was dependent on the material composition, indicating that the catalytic process at hand rather involves a charge transfer process specific to the nanoparticle composition. Semiconductor particles, with or without band-gap engineering, have been shown to possess photocatalytic properties, which can be harnessed, for example, to decompose organic molecules, such as methylene blue or ethylene 42 – 44 . TiO 2 and WO 3 are thought to be particularly effective for production of •OH radicals and photodegradation of organic molecules due to the relative position of their charge and valence band potentials 45 .…”

Section: Resultsmentioning

confidence: 99%

Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

et al. 2022

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Nanoparticle-based radioenhancement is a promising strategy for extending the therapeutic ratio of radiotherapy. While (pre)clinical results are encouraging, sound mechanistic understanding of nanoparticle radioenhancement, especially the effects of nanomaterial selection and irradiation conditions, has yet to be achieved. Here, we investigate the radioenhancement mechanisms of selected metal oxide nanomaterials (including SiO2, TiO2, WO3 and HfO2), TiN and Au nanoparticles for radiotherapy utilizing photons (150 kVp and 6 MV) and 100 MeV protons. While Au nanoparticles show outstanding radioenhancement properties in kV irradiation settings, where the photoelectric effect is dominant, these properties are attenuated to baseline levels for clinically more relevant irradiation with MV photons and protons. In contrast, HfO2 nanoparticles retain some of their radioenhancement properties in MV photon and proton therapies. Interestingly, TiO2 nanoparticles, which have a comparatively low effective atomic number, show significant radioenhancement efficacies in all three irradiation settings, which can be attributed to the strong radiocatalytic activity of TiO2, leading to the formation of hydroxyl radicals, and nuclear interactions with protons. Taken together, our data enable the extraction of general design criteria for nanoparticle radioenhancers for different treatment modalities, paving the way to performance-optimized nanotherapeutics for precision radiotherapy.

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Section: Resultsmentioning

confidence: 99%

Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

et al. 2022

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“…This inherent capability makes them likely to interact effectively with water and oxygen molecules in their environment, facilitated by the substantial band gap (5.7 eV) of HfO 2 , 28 subsequently promoting the production of ROS, such as •OH and 1 O 2 . 29,30 The resulting ROS can cause oxidative damage to cellular components, leading to cell death.…”

Section: Resultsmentioning

confidence: 99%

“…The outcomes outlined above strongly indicate the potential of HfO 2 NPs to serve as inorganic sonosensitizers, a characteristic possibly attributed to their ability to generate high-energy electrons and holes upon activation by US. This inherent capability makes them likely to interact effectively with water and oxygen molecules in their environment, facilitated by the substantial band gap (5.7 eV) of HfO 2 , subsequently promoting the production of ROS, such as •OH and 1 O 2 . , The resulting ROS can cause oxidative damage to cellular components, leading to cell death.…”

Section: Resultsmentioning

confidence: 99%

Harnessing HfO₂ Nanoparticles for Wearable Tumor Monitoring and Sonodynamic Therapy in Advancing Cancer Care

Siboro,

Sharma,

Lai

et al. 2024

ACS Nano

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Addressing the critical requirement for real-time monitoring of tumor progression in cancer care, this study introduces an innovative wearable platform. This platform employs a thermoplastic polyurethane (TPU) film embedded with hafnium oxide nanoparticles (HfO 2 NPs) to facilitate dynamic tracking of tumor growth and regression in real time. Significantly, the synthesized HfO 2 NPs exhibit promising characteristics as effective sonosensitizers, holding the potential to efficiently eliminate cancer cells through ultrasound irradiation. The TPU-HfO 2 film, acting as a dielectric elastomer (DE) strain sensor, undergoes proportional deformation in response to changes in the tumor volume, thereby influencing its electrical impedance. This distinctive behavior empowers the DE strain sensor to continuously and accurately monitor alterations in tumor volume, determining the optimal timing for initiating HfO 2 NP treatment, optimizing dosages, and assessing treatment effectiveness. Seamless integration with a wireless system allows instant transmission of detected electrical impedances to a smartphone for real-time data processing and visualization, enabling immediate patient monitoring and timely intervention by remote medical staff. By combining the dynamic tumor monitoring capabilities of the TPU-HfO 2 film with the sonosensitizer potential of HfO 2 NPs, this approach propels cancer care into the realm of telemedicine, representing a significant advancement in patient treatment.

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“…Meanwhile, the Al element of the tribo-films gradually decreases, which implies the wear degree of Al 2 O 3 ball becomes smaller. In order to further reveal the constituents, the Raman spectra analysis (Figure 9) indicates that the worn surfaces are mainly comprised of metal oxides and a small amount of carbon at 900 • C. [27][28][29][30][31][32] Based on the above results, the tribo-oxidative films are generated on the worn surfaces after completed testing at 900 • C, which are representative worn characteristics of oxidative wear. 11), the enriched wear debris is mainly composed of the metal elements (Hf, Zr, W, V, Nb, Ta, and Ti) of the lower samples.…”

Section: Wear Mechanismmentioning

confidence: 97%

High‐temperature self‐lubricating properties of single‐phase high‐entropy carbides under a vacuum environment

et al. 2023

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It is an enormous challenge to develop single-phase ceramics with satisfactory self-lubricity because of the strong chemical bonding and difficult to shearing. In this study, (Hf 0.2 X 0.2 Nb 0.2 Ta 0.2 Ti 0.2 )C (X is Zr, W, and V, respectively) singlephase high-entropy ceramics can in situ formed tribo-film on the contact region during sliding process to achieve an excellent self-lubricating property. The friction coefficient is as low as 0.34 at 400 • C. This originates from the carbon-rich tribo-films which are generated under the effect of high-temperature triboinduced. With the test temperature increasing, the wear mechanism changes from abrasive wear to oxidative wear. For the 900 • C, the tribo-oxidative film limits the direct contact between tribo-couple and enhances the tribological performances. Moreover, the compositions of the tribo-films also have an important effect on the tribological behaviors. This novel design concept-using own constituent elements to generate a lubricating tribo-film will provide a new strategy for the study of the single-phase self-lubricating ceramics.

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Mn-modified HfO2 nanoparticles with enhanced photocatalytic activity

Cited by 20 publications

References 29 publications

Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

Harnessing HfO₂ Nanoparticles for Wearable Tumor Monitoring and Sonodynamic Therapy in Advancing Cancer Care

High‐temperature self‐lubricating properties of single‐phase high‐entropy carbides under a vacuum environment

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Mn-modified HfO2 nanoparticles with enhanced photocatalytic activity

Cited by 20 publications

References 29 publications

Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

Catalytic activity imperative for nanoparticle dose enhancement in photon and proton therapy

Harnessing HfO2 Nanoparticles for Wearable Tumor Monitoring and Sonodynamic Therapy in Advancing Cancer Care

High‐temperature self‐lubricating properties of single‐phase high‐entropy carbides under a vacuum environment

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Harnessing HfO₂ Nanoparticles for Wearable Tumor Monitoring and Sonodynamic Therapy in Advancing Cancer Care