Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy

Meng, Yingcai; Huang, Jiaxin; Ding, Jinsong; Zhou, Haiyan; Li, Yong; Zhou, Wenhu

doi:10.1016/j.mtbio.2024.101018

Materials Today Bio

2024

DOI: 10.1016/j.mtbio.2024.101018

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Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy

Yingcai Meng,

Jiaxin Huang,

Jinsong Ding

et al.

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2024

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Cited by 2 publications

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A review on the crosstalk between non-coding RNAs and the cGAS-STING signaling pathway

Xiong,

Wang,

et al. 2024

International Journal of Biological Macromolecules

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A review on the crosstalk between non-coding RNAs and the cGAS-STING signaling pathway

Xiong,

Wang,

et al. 2024

International Journal of Biological Macromolecules

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Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy

Lu,

Mi,

Liu

et al. 2024

J Nanobiotechnol

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Engineered Salmonella has emerged as a promising microbial immunotherapy against tumors; however, its clinical effectiveness has encountered limitations. In our investigation, we unveil a non-dose-dependent type of behavior regarding Salmonella’s therapeutic impact and reveal the regulatory role of neutrophils in diminishing the efficacy of this. While Salmonella colonization within tumors recruits a substantial neutrophil population, these neutrophils predominantly polarize into the pro-tumor N2 phenotype, elevating PD-L1 expression and fostering an immunosuppressive milieu within the tumor microenvironment. In order to bypass this challenge, we introduce MnO2 nanoparticles engineered to activate the STING pathway. Harnessing the STING pathway to stimulate IFN-β secretion prompts a shift in neutrophil polarization from the N2 to the N1 phenotype. This strategic repolarization remodels the tumor immune microenvironment, making the infiltration and activation of CD8+ T cells possible. Through these orchestrated mechanisms, the combined employment of Salmonella and MnO2 attains the synergistic enhancement of anti-tumor efficacy, achieving the complete inhibition of tumor growth within 20 days and an impressive 80% survival rate within 40 days, with no discernible signs of significant adverse effects. Our study not only unveils the crucial in vivo constraints obstructing microbial immune therapy but also sets out an innovative strategy to augment its efficacy. These findings pave the way for advancements in cell-based immunotherapy centered on leveraging the potential of neutrophils. Graphical Abstract

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Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy

Cited by 2 publications

References 47 publications

A review on the crosstalk between non-coding RNAs and the cGAS-STING signaling pathway

A review on the crosstalk between non-coding RNAs and the cGAS-STING signaling pathway

Repolarizing neutrophils via MnO2 nanoparticle-activated STING pathway enhances Salmonella-mediated tumor immunotherapy

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