Mn(ii)–hemoporfin-based metal–organic frameworks as a theranostic nanoplatform for MRI-guided sonodynamic therapy

Abstract

Imaging-guided therapy holds great potential for enhancing therapeutic performance in a personalized way. However, it is still challenging to develop appropriate multifunctional materials to overcome the limitations of current all-in-one...

Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers: From Synthesis to Cancer Therapy and Biomedical Imaging

“…In recent years, nanomaterials based on NMOFs/NCPs have gained substantial attention as innovative imaging agents in the field of biomedical imaging. ,− Compared to other nanoparticles, the high porosity and ordered periodic structure of NMOFs/NCPs, along with multiple functional groups on their surfaces, make it possible to encapsulate a large quantity of contrast agents into their cores through postsynthetic modification or load them covalently onto their surfaces. , Additionally, the selection of specific metals or organic compounds with fluorescent properties enables the development of contrast agents based on NMOFs/NCPs, thereby allowing the customization of contrast agents for different imaging techniques such as MRI, CT, and OI. This is essential for monitoring and analyzing intracellular nanoparticles to obtain critical information, thus influencing the optimization of cancer therapies.…”

Advancements and Challenges in the Application of Metal-Organic Framework (MOF) Nanocomposites for Tumor Diagnosis and Treatment

“… 88 Recently, Chen et al advanced this domain by developing Mn 2+ haemoglobin-based MOFs, significantly enhancing both MRI imaging and therapeutic outcomes in tumor applications. 89 So far clinically approved MRI contrast agents (CAs) have not been investigated systematically for the visualization of loading and release from MOF NPs. Konstantin Böll studied the loading and release of six clinically recognised CAs from MOF MIL-100 (Fe) in a clinical MRI environment.…”

“…Computed tomography (CT) emerges as a non-invasive radiological technique that affords three-dimensional visualization of internal structures, distinguished by its high spatial and temporal resolution. 89 The operational principle of CT imaging resides in the differential attenuation of X-rays, which is augmented by contrast agents comprised of elements with high atomic numbers, yielding pronounced X-ray absorption capabilities; this group includes iodine, gold, barium, bismuth, and gadolinium. The challenge, however, Challenges are relatively homogeneous attenuation values for various tissues, high side effects and high cost of contrast media.…”