2024
DOI: 10.1002/adhm.202304484
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Mn2+‐Mediated Modulation of PfAgo Activity for Biosensing

Ruijie Fu,
Jinjie Hou,
Zexiang Wang
et al.

Abstract: Argonaute (Ago) as a powerful enzyme has provided new insights into biosensing due to its programmability, high sensitivity, and user‐friendly operation. However, current strategies mainly rely on phosphorylated guide DNA to modulate the cleavage activity of Ago, which are limited in versatility and simplicity. Herein, we reported Mn2+‐enhanced cleavage activity of Ago and employed Mn ions with variable valence to regulate the activity of Pyrococcus furiosus Ago (PfAgo) for biosensing applications. The convers… Show more

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