Mn⁵⁺ Lifetime‐Based Thermal Imaging in the Optical Transparency Windows Through Skin‐Mimicking Tissue Phantom

Abstract

conditions. We specifically demonstrated that 2D temperature maps of a thermal gradient can be obtained through tissue phantoms mimicking the optical properties of the skin using Ba 3 (VO 4 ) 2 :1% Mn 5+ , 0.5% Er 3+ nanophosphors as luminescent probes and a custom-made setup for lifetime-based luminescence thermometry.These results show the way for the development of ever more efficient luminescent nanothermometers based on doped luminescent centers (i.e., metal ions) that are bright and feature long, temperature-dependent lifetimes. The possibility to remotely and reliably monitor thermal gradients through 2.6 mm of tissue phantom further supports the recent trends in luminescence thermometry of shifting toward lifetime-based approaches, owing to their robustness and higher accuracy.

Probing the Protein Folding Energy Landscape: Dissociation of Amyloid-β Fibrils by Laser-Induced Plasmonic Heating

“…To probe the LSPR heating effect, temperature transient curves were investigated by luminescence thermometry using temperature-sensitive NaYF 4 :Lu/Yb/Er upconverting nanoparticles (UCNPs) coexisting with AuNRs. Luminescence thermometry is a versatile and cost-effective remote sensing technique that uses a temperature-dependent optical signal to measure the local temperature around a light-emitting material. , The technique has become extremely popular over the past decade, as it is effective in remotely measuring temperature in micro- and nanostructured systems. , However, the technique has not been explored to probe the LSPR heating effect in the dissociation of amyloid-β fibrils. Here, a second 980 nm beam laser was added to the setup for the excitation of UCNPs, together with a spectrometer to measure the photoluminescence spectrum (Figure a).…”

“…Luminescence thermometry is a versatile and cost-effective remote sensing technique that uses a temperature-dependent optical signal to measure the local temperature around a light-emitting material. 49,50 The technique has become extremely popular over the past decade, as it is effective in remotely measuring temperature in micro-and nanostructured systems. 51,52 However, the technique has not been explored to probe the LSPR heating effect in the dissociation of amyloid-β fibrils.…”

Critical evaluation of the thermometric performance of ratiometric luminescence thermometers based on Ba3(VO4)2:Mn5+,Nd3+ for deep-tissue thermal imaging

“…Transmission electron microscopy (TEM) studies of Ba 3 (VO 4 ) 2 :0.1% Mn 5+ co-doped with Nd 3+ ions are also in agreement with previous studies for materials singly doped with Mn 5+ ions. 25 It can be concluded that the particles are well crystallized with a tendency to agglomerate (Fig. 1(c)–(f) and Fig.…”

“…Furthermore, the spectra show two broad overlapped bands with maxima at 340 nm and ∼305 nm that come from the charge transfer from the (VO 4 ) 3− group. 25,30 The band centered at 340 nm decreases markedly compared to the band at ∼305 nm as the concentration of Mn 5+ increases, while the maximum of the second band gradually shifts from 312 nm to 301 nm for the phosphor doped with 0.1% and 5% of Mn 5+ ions. This may be related to the gradual decrease in the strength of the crystal field that interacts with the (VO 4 ) 3− group resulting from the substitution of larger Ba 2+ ions with smaller Nd 3+ ions.…”

“…In this vein, recent studies have pointed out at Mn 5+ as an ideal TM for the preparation of luminescence thermometers based on TM and Ln 3+ . [23][24][25][26][27] Indeed, its emission band in the NIR-II region is highly susceptible to thermal quenching. Its spectrally narrow emission also limits overlaps with the NIR emission of co-doped Ln 3+ .…”