MnO<sub>2</sub> Based Bisphenol-A Electrochemical Sensor Using Micro-Fluidic Platform

Khanna, Mansi; Roy, Souradeep; Kumar, Ranjit; Wadhwa, Shikha; Mathur, Ashish; Dubey, Ashwani Kumar

doi:10.1109/jsen.2018.2792476

Cited by 22 publications

(8 citation statements)

References 29 publications

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“…The regression line equation was measured to be I pa (μA) = 0.532log c(nM) + 1.069 with R 2 = 0.983. The limit of detection (LoD) and sensitivity were calculated to be 0.71 nM (using the conventional 3σ rule) and 0.67 μA/nM/mm 2 respectively [23]. Such high sensitivity obtained from CV has also been reported by Monika et.al [51].…”

Section: Tyrosine Sensing Performance Of Smart Band-aidsupporting

confidence: 63%

“…The exploitation of nanomaterials in electrochemical bio-sensors have been intensively explored owing to enhanced surface to volume ratio, thereby opening prospects of diverse functionalization, and quantum confinement effects [15][16][17][18][19][20]. Among the vast array of nanomaterials, MnO 2 nanostructures have garnered considerable interest due to its non-toxic nature which makes them potential biocompatible sensing platforms [21][22][23]. Bai et al reported the voltammetric detection of choline using choline oxidase (ChOx)/MnO 2 /chitosan modified glassy carbon electrode [24].…”

Section: Introductionmentioning

confidence: 99%

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Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

et al. 2020

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L‐tyrosine is an amino acid, the concentration of which is found to be highly elevated in patients suffering from diabetic foot ulcer (DFU). The latter proves to be fatal when it turns out chronic and may lead to amputation. The conventional clinical diagnostic methods are costly and time consuming, in which case, the condition of patient(s) may deteriorate long before proper treatment commences. Herein, we report the development of smart band‐aid for real time monitoring of L‐tyrosine by employing enzymatic bio‐sensor using α‐MnO2/tyrosinase. The smart band‐aid was further integrated with portable electronics capable of wireless data transmission to a personal digital assistant, and its tyrosine sensing performance was evaluated. Anodic current was found to vary linearly with the concentrations of L‐tyrosine in the range of 5 nM–500 μM. The developed sensor displayed a limit of detection and sensitivity of 0.71 nM and 0.67 μA/nM/mm2 respectively, with a stability of 25 days. The developed sensor was validated using a commercial impedance analyzer. The impedance response was found to be consistent with the cyclic voltammogram obtained and demonstrated to be a linear function of tyrosine concentration. The developed sensing platform combines early diagnosis with connected health technologies, thus, fitting well into modern healthcare needs.

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Section: Tyrosine Sensing Performance Of Smart Band-aidsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

et al. 2020

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“…Recently reported EIS sensors and biosensors for EDs detection have used various metal oxides [ 36 ], metal organic frameworks (MOFs) [ 37 ] and molecularly-imprinted polymers (MIPs) [ 38 ], either as supporting layers, or recognition elements. The immobilization strategy and the detection principles will be discussed further.…”

Section: Eis Sensors For Eds Detectionmentioning

confidence: 99%

“…A simple approach is based on the immobilization MnO 2 on a gold electrode and this was integrated into a microfluidic platform [ 36 ]. The system was used for the detection of BPA within a linear range of 1 nM–62.5 µM with a detection limit of 0.66 µM.…”

Section: Eis Sensors For Eds Detectionmentioning

confidence: 99%

Advances in Electrochemical Impedance Spectroscopy Detection of Endocrine Disruptors

Zamfir

Puiu

Bala

2020

Sensors

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Endocrine disruptors (EDs) are contaminants that may mimic or interfere with the body’s hormones, hampering the normal functions of the endocrine system in humans and animals. These substances, either natural or man-made, are involved in development, breeding, and immunity, causing a wide range of diseases and disorders. The traditional detection methods such as enzyme linked immunosorbent assay (ELISA) and chromatography are still the golden techniques for EDs detection due to their high sensitivity, robustness, and accuracy. Nevertheless, they have the disadvantage of being expensive and time-consuming, requiring bulky equipment or skilled personnel. On the other hand, early stage detection of EDs on-the-field requires portable devices fulfilling the Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment free, Deliverable to end users (ASSURED) norms. Electrochemical impedance spectroscopy (EIS)-based sensors can be easily implemented in fully automated, sample-to-answer devices by integrating electrodes in microfluidic chips. The latest achievements on EIS-based sensors are discussed and critically assessed.

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“…These materials exhibit enhanced electron‐transfer kinetics and strong adsorption capability [ 15 ]. Among these nanomaterials, the ‘α’ polymorph of MnO 2 nanostructures has been reported to possess superior catalytic performance owing to variable oxidation states of Mn centres [ 16 , 17 ]. Furthermore, the non‐toxic and easy‐to‐synthesize nature of α‐MnO 2 make them suitable towards the development of electrochemical sensing platforms [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Design and development of a portable resistive sensor based on α‐MnO ₂ /GQD nanocomposites for trace quantification of Pb(II) in water

Gupta‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬‬

Khanna

Roy

et al. 2021

IET Nanobiotechnology

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The occurrence of heavy metal ions in food chain is appearing to be a major problem for mankind. The traces of heavy metals, especially Pb(II) ions present in water bodies remains undetected, untreated, and it remains in the food cycle causing serious health hazards for human and livestock. The consumption of Pb(II) ions may lead to serious medical complications including multiple organ failure which can be fatal. The conventional methods of heavy metal detection are costly, time-consuming and require laboratory space. There is an immediate need to develop a cost-effective and portable sensing system which can easily be used by the common man without any technical knowhow. A portable resistive device with miniaturized electronics is developed with microfluidic well and α-MnO 2 /GQD nanocomposites as a sensing material for the sensitive detection of Pb(II). α-MnO 2 /GQD nanocomposites which can be easily integrated with the miniaturized electronics for realtime on-field applications. The proposed sensor exhibited a tremendous potential to be integrated with conventional water purification appliances (household and commercial) to give an indication of safety index for the drinking water. The developed portable sensor required low sample volume (200 µL) and was assessed within the Pb(II) concentration range of 0.001 nM to 1 uM. The Limit of Detection (LoD) and sensitivity was calculated to be 0.81 nM and 1.05 kΩ/nM/mm 2 , and was validated with the commercial impedance analyser. The shelf-life of the portable sensor was found to be ∼45 days.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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MnO₂ Based Bisphenol-A Electrochemical Sensor Using Micro-Fluidic Platform

Cited by 22 publications

References 29 publications

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

Advances in Electrochemical Impedance Spectroscopy Detection of Endocrine Disruptors

Design and development of a portable resistive sensor based on α‐MnO ₂ /GQD nanocomposites for trace quantification of Pb(II) in water

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MnO2 Based Bisphenol-A Electrochemical Sensor Using Micro-Fluidic Platform

Cited by 22 publications

References 29 publications

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

Electroanalytical Sensor for Diabetic Foot Ulcer Monitoring with Integrated Electronics for Connected Health Application

Advances in Electrochemical Impedance Spectroscopy Detection of Endocrine Disruptors

Design and development of a portable resistive sensor based on α‐MnO 2 /GQD nanocomposites for trace quantification of Pb(II) in water

Contact Info

Product

Resources

About

MnO₂ Based Bisphenol-A Electrochemical Sensor Using Micro-Fluidic Platform

Design and development of a portable resistive sensor based on α‐MnO ₂ /GQD nanocomposites for trace quantification of Pb(II) in water