MnO₂ nanoflowers as a multifunctional nano-platform for enhanced photothermal/photodynamic therapy and MR imaging

Abstract

Photodynamic therapy (PDT) has been regarded as a promising strategy for tumor therapy. However, heterogeneous tumor microenvironment severely limits the efficacy of photodynamic therapy. In this work, a multifunctional theranostic...

Macrophage Membrane-Camouflaged Responsive Polymer Nanogels Enable Magnetic Resonance Imaging-Guided Chemotherapy/Chemodynamic Therapy of Orthotopic Glioma

“…As can be seen in Figure S8, the T 1 relaxation rate ( r 1 ) of MPM@P NGs in the presence of GSH is 9.69 mM –1 s –1 , which is 16-fold higher than that of the same NGs in the absence of GSH (0.57 mM –1 s –1 ). This suggests that the GSH-responsive MPM@P NGs may function as a potential T 1 contrast agent to realize tumor-specific MR imaging. , …”

“…This suggests that the GSHresponsive MPM@P NGs may function as a potential T 1 contrast agent to realize tumor-specific MR imaging. 34,51 In Vitro Cytotoxicity and Cell Apoptosis Assays. To evaluate the GSH depletion-enhanced CDT effect and the combined CDT-chemotherapy efficacy of cancer cells, the viability of C6 cells after different treatments was analyzed by a standard cell counting kit-8 (CCK-8) assay method (Figure S9 and Figure 2A).…”

The Combination of Solid-State Chemistry and Medicinal Chemistry as the Basis for the Synthesis of Theranostics Platforms

“…In Reference [27], a theranostic platform (MnO 2 -SiO 2 -APTES and Ce6; MSA & C) based on MnO 2 nanoflowers was synthesized, which provides synergistic therapy guided by MRI, including PDT and PTT in the second near-infrared window (NIR-II). Nanoflowers refer to chemical compounds that form structures that, under TEM, resemble flowers (or, in some cases, trees), sometimes called nanobouquets or nanotrees.…”

Recent Progress on NIR-II Photothermal Therapy

“…The key to the applications of the NIR-II absorption materials in PTT is that the materials should have good photothermal conversion efficiency, low biological toxicity and easy functionalization. Studies show that Au nanomaterials ( Deng et al, 2019 ; Song et al, 2019 ; Wang et al, 2020c ; Jia et al, 2020 ), metal sulfur oxides ( Lin et al, 2020a ; Sun et al, 2021 ) such as Ag 2 S ( Yang et al, 2017b ) and MoO 2 ( Guo et al, 2020 ), two-dimensional nanomaterials such as MoS 2 ( Shi et al, 2020 ), niobium carbide (MXene) ( Lin et al, 2017b ) and SnTe ( Zhang et al, 2019a ), and polymers ( Sun et al, 2019a ) such as semiconductor polymer nanoparticles SPN 1 ( Jiang et al, 2018b ), SPN 2 ( Yin et al, 2020 ), SPN 3 ( Cao et al, 2018b ) can be applied for NIR-II PTT. By modifying the photothermal materials, researchers can improve their photostability, chemical stability, biocompatibility, and endow them with some new functions, such as targeting and drug delivery.…”